3.4.24.36: leishmanolysin

This is an abbreviated version, for detailed information about leishmanolysin, go to the full flat file.

Reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-/-Leu-Lys-Lys- =

Synonyms

66 kDa surface metallopeptidase, Cell surface protease, Glycoprotein gp63, gp63, GP63 protein, GP63 surface metalloprotease, Leishmania metalloproteinase, Leishmania surface metalloprotease, leishmanolysin-like molecule, Major surface glycoprotein, major surface protease, major surface-metalloprotease, MSP, Promastigote surface endopeptidase, Promastigote surface protease, protective surface protease, Surface acid proteinase, surface leishmanolysin-like molecule, surface protease GP63, surface protein GP63, surface proteinase GP63

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.36 leishmanolysin

Cloned

Cloned on EC 3.4.24.36 - leishmanolysin

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
construction of full-length gp63 gene in mammalian pcDNA3.1 (2/2) expression vector, expression in CHO cells and of His-tagged protein in Escherichia coli BL21 (DE3) pLysS
DNA and amino acid sequence determination, analysis and comparison, overexpression in Escherichia coli strain BL21 (DE3) pLysS
expressed in Escherichia coli JM109(DE3)
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expression in Escherichia coli
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genes gp63, DNA and amino acid sequence determination and analysis, sequence analysis and identification of homologues of major surface protease genes and sequence comparisons, phylogenetic analysis
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