3.4.24.36: leishmanolysin

This is an abbreviated version, for detailed information about leishmanolysin, go to the full flat file.

Reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-/-Leu-Lys-Lys- =

Synonyms

66 kDa surface metallopeptidase, Cell surface protease, Glycoprotein gp63, gp63, GP63 protein, GP63 surface metalloprotease, Leishmania metalloproteinase, Leishmania surface metalloprotease, leishmanolysin-like molecule, Major surface glycoprotein, major surface protease, major surface-metalloprotease, MSP, Promastigote surface endopeptidase, Promastigote surface protease, protective surface protease, Surface acid proteinase, surface leishmanolysin-like molecule, surface protease GP63, surface protein GP63, surface proteinase GP63

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.36 leishmanolysin

Reference

Reference on EC 3.4.24.36 - leishmanolysin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chaudhuri, G.; Chaudhuri, M.; Pan, A.; Chang, K.P.
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages
J. Biol. Chem.
264
7483-7489
1989
Leishmania amazonensis, Leishmania amazonensis LV78, Leishmania mexicana pifanoi
Manually annotated by BRENDA team
Bouvier, J.; Schneider, P.; Etges, R.; Bordier, C.
Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania
Biochemistry
29
10113-10119
1990
Leishmania sp.
Manually annotated by BRENDA team
Schlagenhauf, E.; Etges, R.; Metcalf, P.
Crystallization and preliminary X-ray diffraction studies of leishmanolysin, the major surface metalloproteinase from Leishmania major
Proteins Struct. Funct. Genet.
22
58-66
1995
Leishmania major
Manually annotated by BRENDA team
Bouvier, J.; Schneider, P.; Etges, R.
Leishmanolysin: surface metalloproteinase of Leishmania
Methods Enzymol.
248
614-633
1995
Leishmania amazonensis, Leishmania infantum, Leishmania major
Manually annotated by BRENDA team
Corradin, S.; Ransijn, A.; Corradin, G.; Roggero, M.A.; Schmitz, A.A.; Schneider, P.; Mauel, J.; Vergeres, G.
MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63)
J. Biol. Chem.
274
25411-25418
1999
Leishmania major, Leishmania major LV39
Manually annotated by BRENDA team
Schlagenhauf, E.; Etges, R.; Metcalf, P.
The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63)
Structure
6
1035-1046
1998
Leishmania major, Leishmania major (P08148), Leishmania major LRC-L119 (P08148)
Manually annotated by BRENDA team
Sadlova, J.; Volf, P.; Victoir, K.; Dujardin, J.C.; Votypka, J.
Virulent and attenuated lines of Leishmania major: DNA karyotypes and differences in metalloproteinase GP63
Folia Parasitol.
53
81-90
2006
Leishmania major
Manually annotated by BRENDA team
Pandey, S.; Chakraborti, P.; Sharma, R.; Bandyopadhyay, S.; Sarkar, D.; Adhya, S.
Involvement of Leishmania donovani major surface glycoprotein gp63 in promastigote multiplication
J. Biosci.
29
15-22
2004
Leishmania donovani
Manually annotated by BRENDA team
Yao, C.; Luo, J.; Storlie, P.; Donelson, J.E.; Wilson, M.E.
Multiple products of the Leishmania chagasi major surface protease (MSP or GP63) gene family
Mol. Biochem. Parasitol.
135
171-183
2004
Leishmania chagasi, Leishmania chagasi (P15706)
Manually annotated by BRENDA team
Yao, C.; Luo, J.; Hsiao, C.; Donelson, J.E.; Wilson, M.E.
Internal and surface subpopulations of the major surface protease (MSP) of Leishmania chagasi
Mol. Biochem. Parasitol.
139
173-183
2005
Leishmania chagasi
Manually annotated by BRENDA team
Bianchini, G.; Bocedi, A.; Ascenzi, P.; Gavuzzo, E.; Mazza, F.; Aschi, M.
Molecular dynamics simulation of Leishmania major surface metalloprotease GP63 (leishmanolysin)
Proteins
64
385-390
2006
Leishmania major
Manually annotated by BRENDA team
Porter-Kelley, J.; Seay, M.; Singh, P.K.; Chaudhuri, G.
Bio-available Zn2+ in the growth medium as a cue for Leishmania to express its protective surface protease
Ann. Trop. Med. Parasitol.
101
89-93
2007
Leishmania amazonensis
Manually annotated by BRENDA team
Yao, C.; Donelson, J.E.; Wilson, M.E.
Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes
Eukaryot. Cell
6
1905-1912
2007
Leishmania chagasi, Leishmania chagasi MHOM/BR/00/1669
Manually annotated by BRENDA team
Hsiao, C.C.; Yao, C.; Storlie, P.; Donelson, J.E.; Wilson, M.E.
The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi
Mol. Biochem. Parasitol.
157
148-159
2008
Leishmania chagasi, Leishmania chagasi MHOM/BR/00/1669
Manually annotated by BRENDA team
Kulkarni, M.M.; McMaster, W.R.; Kamysz, E.; Kamysz, W.; Engman, D.M.; McGwire, B.S.
The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing
Mol. Microbiol.
62
1484-1497
2006
Leishmania major
Manually annotated by BRENDA team
Razzazan, A.; Saberi, M.R.; Jaafari, M.R.
Insights from the analysis of a predicted model of gp63 in Leishmania donovani
Bioinformation
3
114-118
2008
Leishmania donovani, Leishmania donovani (P23223)
Manually annotated by BRENDA team
Lieke, T.; Nylen, S.; Eidsmo, L.; McMaster, W.R.; Mohammadi, A.M.; Khamesipour, A.; Berg, L.; Akuffo, H.
Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation
Clin. Exp. Immunol.
153
221-230
2008
Leishmania major, Leishmania major (P08148)
Manually annotated by BRENDA team
Badiee, A.; Jaafari, M.R.; Khamesipour, A.; Samiei, A.; Soroush, D.; Kheiri, M.T.; Barkhordari, F.; McMaster, W.R.; Mahboudi, F.
The role of liposome charge on immune response generated in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63)
Exp. Parasitol.
121
362-369
2009
Leishmania major
Manually annotated by BRENDA team
Bhowmick, S.; Ravindran, R.; Ali, N.
gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani
Infect. Immun.
76
1003-1015
2008
Leishmania donovani
Manually annotated by BRENDA team
Halle, M.; Gomez, M.A.; Stuible, M.; Shimizu, H.; McMaster, W.R.; Olivier, M.; Tremblay, M.L.
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation
J. Biol. Chem.
284
6893-6908
2009
Leishmania major
Manually annotated by BRENDA team
Pereira, F.M.; Dias, F.A.; Elias, C.G.; dAvila-Levy, C.M.; Silva, C.S.; Santos-Mallet, J.R.; Branquinha, M.H.; Santos, A.L.
Leishmanolysin-like molecules in Herpetomonas samuelpessoai mediate hydrolysis of protein substrates and interaction with insect
Protist
161
589-602
2010
Herpetomonas pessoai
Manually annotated by BRENDA team
Gomez, M.A.; Contreras, I.; Halle, M.; Tremblay, M.L.; McMaster, R.W.; Olivier, M.
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases
Sci. Signal.
2
ra58
2009
Leishmania sp.
Manually annotated by BRENDA team
Ferreira, K.A.; Ruiz, J.C.; Dias, F.C.; Lages-Silva, E.; Tosi, L.R.; Ramirez, L.E.; Pedrosa, A.L.
Genome survey sequence analysis and identification of homologs of major surface protease (gp63) genes in Trypanosoma rangeli
Vector Borne Zoonotic Dis.
10
847-853
2010
Trypanosoma rangeli, Trypanosoma rangeli P07
Manually annotated by BRENDA team
Mazumder, S.; Ganguly, A.; Ali, N.
The effect of C-terminal domain deletion on the catalytic activity of Leishmania donovani surface proteinase GP63: Role of Ser446 in proteolysis
Biochimie
92
1876-1885
2010
Leishmania donovani donovani (C7EX18), Leishmania donovani donovani MHOM/IN/1983/AG83 (C7EX18)
Manually annotated by BRENDA team
Lynn, M.A.; Kindrachuk, J.; Marr, A.K.; Jenssen, H.; Pante, N.; Elliott, M.R.; Napper, S.; Hancock, R.E.; McMaster, W.R.
Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival
PLoS Negl. Trop. Dis.
5
e1141
2011
Leishmania major, Leishmania major MHOM/IL/80/Friedlin
Manually annotated by BRENDA team
Mazumder, S.; Maji, M.; Das, A.; Ali, N.
Potency, efficacy and durability of DNA/DNA, DNA/protein and protein/protein based vaccination using gp63 against Leishmania donovani in BALB/c mice
PLoS ONE
6
e14644
2011
Leishmania donovani (C7EX18)
Manually annotated by BRENDA team
Contreras, I.; Gomez, M.; Nguyen, O.; Shio, M.; McMaster, R.; Olivier, M.
Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63
PLoS Pathog.
6
e1001148
2010
Leishmania donovani
Manually annotated by BRENDA team