3.4.23.43: prepilin peptidase

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For detailed information about prepilin peptidase, go to the full flat file.

Reaction

typically cleaves a -Gly-/-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine =

Synonyms

ComC, HofD, More, PibD, PilD, PilD-like protein, Pilin leader peptidase, PilU, pre-pseudopilin peptidase, preflagellin peptidase, Prepilin peptidase, prepilin peptidase PilD/XcpA, proepilin peptidase PulO, proteinase, pilin precursor, PulO, PulO prepilin peptidase, TadV protein, TcpJ, TFPP, type 4 prepilin peptidase, type 4 prepilin-like proteins leader peptide-processing enzyme, type IV prepilin peptidase, type IV prepilin-like peptidase, VcpD, XcpA, XpsO

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.43 prepilin peptidase

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Results	in table
14005	AA Sequence
3	Application
1	CAS Registry Number
7	Cloned(Commentary)
8	General Information
6	Inhibitors
1	KM Value [mM]
14	Localization
1	Metals/Ions
40	Natural Substrates/ Products (Substrates)
52	Organism
2	pI Value
74	Protein Variants
4	Purification (Commentary)
3	Reaction
1	Reaction Type
42	Reference
71	Substrates and Products (Substrate)
10	Subunits
66	Synonyms
1	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.23.43 - prepilin peptidase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

2 entries

expression in Escherichia coli in inner membrane vesicles

Saccharolobus solfataricus

Q6IFS8

669116

gene fppA, DNA and amino acid sequence determination and analysis, expression of wild-type and mutants in strain PAO1, method optimization

Pseudomonas aeruginosa

-

669123

gene pilU, expression of wild-type and mutant enzymes from plasmid R64 in strain DH5alpha and BL21(DE3)

Escherichia coli

-

670275

gene tadV, DNA and amino acid sequence determination and analysis, functional expression of wild-type enzyme in Escherichia coli strain BL21(DE3)

Aggregatibacter actinomycetemcomitans

-

669128

pilD mutants with excretion defect, expression in Escherichia coli DH5alpha

Pseudomonas aeruginosa

-

666764

-

Pseudomonas aeruginosa

-

137313

-

Vibrio cholerae serotype O1

-

137312