3.4.23.43: prepilin peptidase
This is an abbreviated version!
For detailed information about prepilin peptidase, go to the full flat file.
Word Map on EC 3.4.23.43
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3.4.23.43
-
pilins
-
fimbrial
-
oxytoca
-
pseudopilins
-
pullulanase
-
bundle-forming
-
preflagellins
-
exoproteins
-
type-iv
-
synthesis
-
medicine
- 3.4.23.43
- pilins
-
fimbrial
- oxytoca
- pseudopilins
- pullulanase
-
bundle-forming
- preflagellins
-
exoproteins
- type-iv
- synthesis
- medicine
Reaction
typically cleaves a -Gly-/-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine =
Synonyms
ComC, HofD, More, PibD, PilD, PilD-like protein, Pilin leader peptidase, PilU, pre-pseudopilin peptidase, preflagellin peptidase, Prepilin peptidase, prepilin peptidase PilD/XcpA, proepilin peptidase PulO, proteinase, pilin precursor, PulO, PulO prepilin peptidase, TadV protein, TcpJ, TFPP, type 4 prepilin peptidase, type 4 prepilin-like proteins leader peptide-processing enzyme, type IV prepilin peptidase, type IV prepilin-like peptidase, VcpD, XcpA, XpsO
ECTree
3.4.23.43 prepilin peptidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.23.43 - prepilin peptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
prePulG + H2O
?
-
processing of proteins which are required for pullulanase secretion
-
-
?
Flp1 prepilin + H2O
Flp1 pilin + Flp1 prepilin leader peptide
-
-
-
-
?
Flp1 prepilin + H2O
Flp1 pilin + Flp1 prepilin leader peptide
-
the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pseudopilins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms
-
-
?
GspG prepseudopilin + H2O
GspG pseudopilin + GspG prepseudopilin leader peptide
-
-
-
-
?
GspG prepseudopilin + H2O
GspG pseudopilin + GspG prepseudopilin leader peptide
-
-
-
-
?
preflagellin + H2O
flagellin + preflagellin leader peptide
-
-
-
-
?
preflagellin + H2O
flagellin + preflagellin leader peptide
-
-
-
?
prepilin PilA + H2O
?
-
cosynthesis of PilD with its full-length substrate, PilA, leads to complete cleavage of the substrate signal peptides
-
?
prepilin PilA + H2O
?
-
cosynthesis of PilD with its full-length substrate, PilA, leads to complete cleavage of the substrate signal peptides
-
?
prepilin PilA + H2O
pilin PilA + prepilin PilA leader peptide
-
-
-
-
?
prepilin PilA + H2O
pilin PilA + prepilin PilA leader peptide
-
-
-
-
?
prepilin PilB + H2O
pilin PilB + prepilin PilB leader peptide
-
-
-
-
?
prepilin PilB + H2O
pilin PilB + prepilin PilB leader peptide
-
-
-
-
?
prepilin PilC + H2O
pilin PilC + prepilin PilC leader peptide
-
-
-
-
?
prepilin PilC + H2O
pilin PilC + prepilin PilC leader peptide
-
-
-
-
?
prepilin PilE1 + H2O
pilin PilE1 + prepilin PilE1 leader peptide
-
-
-
-
?
prepilin PilE1 + H2O
pilin PilE1 + prepilin PilE1 leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + leader peptide
-
prepilin maturation is required for extracellular protein secretion, and competence state and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion of degradative enzymes and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
the consensus sequence of the cleavage site is Gly-Phe or Gly-Met within Gly-Phe/Met-Thr-Leu-Ile/Leu-Glu
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
Legionella pneumoniae
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
Legionella pneumoniae
-
prepilin maturation is required for extracellular protein secretion and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
the consensus sequence of the cleavage site is Gly-Phe or Gly-Met within Gly-Phe/Met-Thr-Leu-Ile/Leu-Glu
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
the consensus sequence of the cleavage site is Gly-Phe or Gly-Met within Gly-Phe/Met-Thr-Leu-Ile/Leu-Glu
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion of degradative enzymes and DNA uptake, overview
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
-
-
-
?
prepilin type IV + H2O
pilin type IV + prepilin type IV leader peptide
-
prepilin maturation is required for extracellular protein secretion of degradative enzymes and DNA uptake, overview
-
-
?
TadE prepseudopilin + H2O
TadE pseudopilin + TadE prepseudopilin leader peptide
-
-
-
-
?
TadE prepseudopilin + H2O
TadE pseudopilin + TadE prepseudopilin leader peptide
-
the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pilin-like proteins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms
-
-
?
TadF prepseudopilin + H2O
TadF pseudopilin + TadF prepseudopilin leader peptide
-
-
-
-
?
TadF prepseudopilin + H2O
TadF pseudopilin + TadF prepseudopilin leader peptide
-
the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pilin-like proteins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms
-
-
?
type IV Flp1 prepilin + H2O
type IV Flp1 pilin + type IV Flp1 prepilin leader peptide
-
-
-
-
?
type IV Flp1 prepilin + H2O
type IV Flp1 pilin + type IV Flp1 prepilin leader peptide
-
maturation of pilin type IV, the enzyme is involved in the assembly of type IVb pili required for motility and attachment, overview
-
-
?
additional information
?
-
-
activity rate with different recombinant mutants of Flp1, TadE, and TadF constructed by site-directed mutagenesis and expressed in Escherichia coli, overview
-
-
?
additional information
?
-
-
the enzyme is involved in secretion of pullulanase
-
-
?
additional information
?
-
Legionella pneumoniae
-
the enzyme is involved in type II secretion pathway and intracellular survival
-
-
?
additional information
?
-
-
additionally catalyzes the N-methylation of the newly exposed N-terminal amino acid
-
-
?
additional information
?
-
-
additionally catalyzes the N-methylation of the newly exposed N-terminal amino acid
-
-
?
additional information
?
-
enzyme additionally catalyzes S-adenosyl methionine-dependent methylation of the mature pilin
-
-
?
additional information
?
-
-
enzyme additionally catalyzes S-adenosyl methionine-dependent methylation of the mature pilin
-
-
?
additional information
?
-
enzyme additionally catalyzes S-adenosyl methionine-dependent methylation of the mature pilin
-
-
?
additional information
?
-
the enzyme cleaves sugar-binding proteins unique to Sulfolobus solfataricus
-
-
?
additional information
?
-
-
the enzyme cleaves sugar-binding proteins unique to Sulfolobus solfataricus
-
-
?
additional information
?
-
-
processing by the prepilin peptidase PilD occurs after Gly-1
-
-
?
additional information
?
-
-
processing by the prepilin peptidase PilD occurs after Gly-1
-
-
?
additional information
?
-
-
processing of Eps preplilin-like proteins and Msh prepilins required for cholera toxin secretion
-
-
?
additional information
?
-
-
the loss of PilD significantly reduces the ability of Vibrio vulnificus to persist in Crassostrea virginica over a 66 h interval, strongly suggesting that pili expressed by this bacterium play a role in colonization or persistence in oysters
-
-
?
