3.4.23.3: gastricsin
This is an abbreviated version!
For detailed information about gastricsin, go to the full flat file.
Word Map on EC 3.4.23.3
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3.4.23.3
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mucosa
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pylori
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helicobacter
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gastritis
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stomach
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atrophic
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gastrin
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ulcer
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zymogen
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proteinases
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endoscopy
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duodenal
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peptic
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metaplasia
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fundic
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gastrin-17
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pepstatin
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antral
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pylori-positive
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dyspeptic
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prochymosin
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chymosin
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gastroduodenal
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3.4.23.1
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diffuse-type
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isozymogens
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pylori-negative
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prosegment
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anti-helicobacter
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medicine
- 3.4.23.3
- mucosa
- pylori
- helicobacter
- gastritis
- stomach
-
atrophic
- gastrin
- ulcer
- zymogen
- proteinases
-
endoscopy
- duodenal
-
peptic
- metaplasia
- fundic
- gastrin-17
- pepstatin
-
antral
-
pylori-positive
-
dyspeptic
- prochymosin
- chymosin
-
gastroduodenal
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3.4.23.1
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diffuse-type
-
isozymogens
-
pylori-negative
- prosegment
-
anti-helicobacter
- medicine
Reaction
additional information restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin =
Synonyms
EC 3.4.4.22, More, parapepsin II, pepsin C, pepsin II, pepsinogen C, pepsinogen II, PGC, pig parapepsin II, progastricsin, seminal pepsin
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General Information
General Information on EC 3.4.23.3 - gastricsin
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physiological function
the major useful function of progastricsin (PGC) includes production of pro-antimicrobial substance in seminal plasma. The action of PGC in the stomach is to degrade dietary proteins. However, in seminal fluid, it activates defensins for local antimicrobial defense. On the other hand, intracellular proprotein activation by PGC in acidic organelle, such as in proSP-B proteolysis, is important on the processing in the secretory pathway of alveolar type-2 cells
physiological function
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the enzyme plays a tumorigenesis role in hepatocellular carcinoma progression