3.4.23.3: gastricsin
This is an abbreviated version!
For detailed information about gastricsin, go to the full flat file.
Word Map on EC 3.4.23.3
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3.4.23.3
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mucosa
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pylori
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helicobacter
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gastritis
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stomach
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atrophic
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gastrin
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ulcer
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zymogen
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proteinases
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endoscopy
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duodenal
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peptic
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metaplasia
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fundic
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gastrin-17
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pepstatin
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antral
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pylori-positive
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dyspeptic
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prochymosin
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chymosin
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gastroduodenal
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3.4.23.1
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diffuse-type
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isozymogens
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pylori-negative
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prosegment
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anti-helicobacter
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medicine
- 3.4.23.3
- mucosa
- pylori
- helicobacter
- gastritis
- stomach
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atrophic
- gastrin
- ulcer
- zymogen
- proteinases
-
endoscopy
- duodenal
-
peptic
- metaplasia
- fundic
- gastrin-17
- pepstatin
-
antral
-
pylori-positive
-
dyspeptic
- prochymosin
- chymosin
-
gastroduodenal
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3.4.23.1
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diffuse-type
-
isozymogens
-
pylori-negative
- prosegment
-
anti-helicobacter
- medicine
Reaction
additional information restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin =
Synonyms
EC 3.4.4.22, More, parapepsin II, pepsin C, pepsin II, pepsinogen C, pepsinogen II, PGC, pig parapepsin II, progastricsin, seminal pepsin
ECTree
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Inhibitors
Inhibitors on EC 3.4.23.3 - gastricsin
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alpha2-Macroglobulin
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activity with reduced and carboxymethylated ribonuclease A is significantly inhibited, activity with oxidized insulin B-chain is scarcely inhibited
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N-(morpholine-4-sulfonyl)-L-phenylalanyl-N-[(2S,3S,5S)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]-N6-(methylcarbamothioyl)lysinamide
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N-[(2S)-1-([(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino)-1-oxopent-4-en-2-yl]-Nalpha-(morpholine-4-sulfonyl)-L-phenylalaninamide
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N-[(2S)-1-([(2S,3S,5S)-1-cyclohexyl-3,5-dihydroxy-6-methylheptan-2-yl]amino)-1-oxopent-4-en-2-yl]-Nalpha-(morpholine-4-sulfonyl)-L-phenylalaninamide
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additional information
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the pepsin C activity decreases due to its autocatalytical activity
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pepstatin
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100 molar excess amount is needed for the complete inhibition of activity of pepsin C-1 and C-2