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3.4.23.3: gastricsin

This is an abbreviated version!
For detailed information about gastricsin, go to the full flat file.

Word Map on EC 3.4.23.3

Reaction

additional information restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin =

Synonyms

EC 3.4.4.22, More, parapepsin II, pepsin C, pepsin II, pepsinogen C, pepsinogen II, PGC, pig parapepsin II, progastricsin, seminal pepsin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.3 gastricsin

Inhibitors

Inhibitors on EC 3.4.23.3 - gastricsin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-epoxy-(p-nitrophenoxy)propane
-
-
1,2-epoxy-3-(p-nitrophenoxy)propane
-
-
Acetyl-Phe
-
hydrolysis of acetyl-Phe-Leu-Val-His-amide
alpha2-Macroglobulin
-
activity with reduced and carboxymethylated ribonuclease A is significantly inhibited, activity with oxidized insulin B-chain is scarcely inhibited
-
Diazoacetyl-DL-norleucine methyl ester
isovaleryl pepstatin
-
-
L-363,564
-
a statyl peptide based on renin substrate angiotensinogen
L-364099
-
-
lactoyl-pepstatin
-
very weakly
N-(morpholine-4-sulfonyl)-L-phenylalanyl-N-[(2S,3S,5S)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]-N6-(methylcarbamothioyl)lysinamide
-
-
N-[(2S)-1-([(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino)-1-oxopent-4-en-2-yl]-Nalpha-(morpholine-4-sulfonyl)-L-phenylalaninamide
-
-
N-[(2S)-1-([(2S,3S,5S)-1-cyclohexyl-3,5-dihydroxy-6-methylheptan-2-yl]amino)-1-oxopent-4-en-2-yl]-Nalpha-(morpholine-4-sulfonyl)-L-phenylalaninamide
-
-
p-bromophenylacyl bromide
-
-
pepstatin
pepstatin A
-
-
additional information
-
the pepsin C activity decreases due to its autocatalytical activity
-