3.4.23.21: Rhizopuspepsin

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For detailed information about Rhizopuspepsin, go to the full flat file.

Reaction

hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave Gln4-His, but does cleave His10-/-Leu and Val12-/-Glu in B chain of insulin =

Synonyms

Aspartate protease, aspartic peptidase, EC 3.4.23.6, EC 3.4.23.9, EC 3.4.4.17, EC 3.4.99.25, More, Neurase, Proteinase, Rhizopus acid, Rhizopus acid protease, Rhizopus acid proteinase, Rhizopus aspartic proteinase, rhizopuspepsinogen

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.21 Rhizopuspepsin

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Results	in table
340	AA Sequence
3	Application
1	CAS Registry Number
8	Cloned(Commentary)
10	Crystallization (Commentary)
42	Inhibitors
1	kcat/KM [mM/s]
3	Ki Value [mM]
32	KM Value [mM]
4	Localization
4	Metals/Ions
16	Molecular Weight [Da]
36	Organism
6	pH Optimum
3	pH Range
3	pH Stability
2	pI Value
12	Purification (Commentary)
2	Reaction
1	Reaction Type
36	Reference
1	Renatured (Commentary)
1	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
53	Substrates and Products (Substrate)
6	Subunits
16	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
29	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.23.21 - Rhizopuspepsin

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2

Rhizopus niveus

-

0.1 M tartrate buffer, 24 h, loses most of its activity, retains its high activity if incubated in 0.1 M tartrate buffer of pH 3.0-4.0 or in 1.0 M acetate buffer of pH 4.5-5.5

30606

3 - 5

Rhizomucor miehei

-

the peptidase is stable at pH values ranging from 3.0 to 5.0 for 1 h

743030

6.5 - 7.5

Rhizopus niveus

-

0.1 M phosphate buffer, 24 h, loses most of its activity, retains its high activity if incubated in 0.1 M tartrate buffer of pH 3.0-4.0 or in 1.0 M acetate buffer of 4.5-5.5

30606