3.4.23.2: pepsin B

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For detailed information about pepsin B, go to the full flat file.

Reaction

degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin additional information restricted than that of pepsin A; does not cleave at Phe1-Val, Gln4-His or Gly23-Phe =

Synonyms

EC 3.4.4.2, gelatinase, More, parapepsin I, pepsin, Pepsina Suina TS

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.2 pepsin B

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Results	in table
3	Activating Compound
7	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
2	General Stability
5	Inhibitors
14	KM Value [mM]
4	Metals/Ions
7	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
12	Organism
4	pH Optimum
4	pH Range
5	pH Stability
6	Posttranslational Modification
7	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
12	Reference
10	Source Tissue
4	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
6	Subunits
7	Synonyms
3	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
14	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.23.2 - pepsin B

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

EDTA

Albatrossia pectoralis

-

2 mM, 12.31% inhibition

679335

NaCl

Albatrossia pectoralis

-

30%, activity of pepsin B decreases by 60-65%

679335

pepstatin A

Albatrossia pectoralis

-

0.01 mM, 96.7% inhibition

679335

SDS

Sus scrofa

-

When SDS concentration is below its critical micellar concentration (less than 0.05% (w/v)), the enzyme activity is reduced about 50% of its initial value. When SDS concentration is at 0.05% (w/v) or above, a 10% or less of its initial value is obtained

755370

additional information

Sus scrofa

-

cetyltrimethyl ammonium bromide, Tween 80, and Triton X-100 do not alter the enzymatic activity at any concentration assayed

755370

-