3.4.22.B29: calpain 9

This is an abbreviated version!
For detailed information about calpain 9, go to the full flat file.

Reaction

broad endopeptidase specificity =

Synonyms

calpain 9, calpain-9, CAPN9, digestive tract-specific calpain, nCL-4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B29 calpain 9

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
4	AA Sequence
3	Application
1	CAS Registry Number
4	Cloned(Commentary)
1	Crystallization (Commentary)
56	Disease/ Diagnostics
3	General Information
4	Inhibitors
5	Metals/Ions
1	Natural Substrates/ Products (Substrates)
19	Organism
1	Protein Variants
1	Purification (Commentary)
1	Reaction
2	Reaction Type
17	Reference
25	Source Tissue
5	Substrates and Products (Substrate)
7	Synonyms

Disease

topprint

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Disease on EC 3.4.22.B29 - calpain 9

Please use the Disease Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adenocarcinoma

Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.

23329366

Albuminuria

Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease.

15665521

Alzheimer Disease

The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.

17157313

Breast Neoplasms

Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.

25539577

Carcinogenesis

Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis.

10906334

Carcinogenesis

Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.

20686710

Carcinogenesis

Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.

27404891

Carcinogenesis

Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/?-catenin signaling while up-regulating ligand dependent transcription factor PPAR?

24721324

Colorectal Neoplasms

Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: Exploring NHE-1, intracellular calcium homeostasis and Calpain 9.

22390894

Diabetes Mellitus, Type 2

The calpain family and human disease.

11516996

Kidney Diseases

Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease.

15665521

Lymphatic Metastasis

Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.

27404891

Neoplasm Metastasis

Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.

27404891

Neoplasms

Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.

27404891

Stomach Neoplasms

Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.

27404891

Stomach Neoplasms

Isolation of two novel genes, down-regulated in gastric cancer.

10835488

Stomach Neoplasms

The calpain family and human disease.

11516996

Stomach Neoplasms

The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.

17157313

html completed