Information on EC 3.4.22.B29 - calpain 9

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.22.B29
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
calpain 9
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
broad endopeptidase specificity
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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endopeptidase; peptides, endopeptidase
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CAS REGISTRY NUMBER
COMMENTARY hide
78990-62-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain C57BL/6J
SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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inhibition of CAPN9 expression in MCF7/CEACAM1-4S cells by RNAi or by calpeptin or PD150606 inhibits lumen formation
physiological function
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calpain-9 may play a role in breast cance, low expression is associated with poorer patient clinical outcome following endocrine therapy, but no associations are observed between calpain-9 expression and clinicopathological variables
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
peptide + H2O
hydrolyzed peptide
show the reaction diagram
additional information
?
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specialized functions of nCL-4 in the digestive tract
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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specialized functions of nCL-4 in the digestive tract
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
calpastatin
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Calpeptin
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pan-calpain inhibitor
NaCl
4% down-regulates the enzyme by more than 50% in the kidney and heart but not in the aorta
PD150606
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pan-calpain inhibitor
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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expression analysis
Manually annotated by BRENDA team
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expression analysis
Manually annotated by BRENDA team
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suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types
Manually annotated by BRENDA team
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; transfected with CEACAM1-4S (carcinoembryonic antigen-related cell adhesion molecule 1), a type I membrane protein with a short (12-amino acid) cytoplasmic tail
Manually annotated by BRENDA team
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predominantly expressed in
Manually annotated by BRENDA team
additional information
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no expression in the uterus
Manually annotated by BRENDA team
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method, minicalpain 9. The structures of the highly conserved, ubiquitously expressed human calpain 1 and the more tissue specific human calpain 9 indicate that although there are high levels of sequence conservation throughout the calpain family, isolated structures of family members are insufficient to explain the molecular mechanism of activation for this group of proteins
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
overexpression in COS-7 cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
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low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer, but no associations are observed between calpain-9 expression and clinicopathological variables
medicine
differential regulation of calpain 9 plays a role in hypertensive target organ damage