3.4.22.42: cathepsin O

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For detailed information about cathepsin O, go to the full flat file.

Reaction

The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec =

Synonyms

CTSO, procathepsin O, TmO12

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.42 cathepsin O

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Reaction

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Reaction on EC 3.4.22.42 - cathepsin O

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec

Cathepsin O is a lysosomal cysteine peptidase of family C1, papain family. The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32

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