3.4.22.42: cathepsin O

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For detailed information about cathepsin O, go to the full flat file.

Reaction

The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec =

Synonyms

CTSO, procathepsin O, TmO12

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.42 cathepsin O

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Results	in table
12	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
10	Disease/ Diagnostics
4	Expression
2	General Information
3	Inhibitors
1	Localization
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
9	Organism
1	pI Value
1	Posttranslational Modification
1	Reaction
1	Reaction Type
9	Reference
41	Source Tissue
4	Substrates and Products (Substrate)
1	Subunits
3	Synonyms

Disease

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Disease on EC 3.4.22.42 - cathepsin O

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.

7929457

Breast Neoplasms

SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ER?-positive breast cancer through regulation of BRCA1.

28968398

Carcinoma

Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.

7929457

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