3.4.21.96: Lactocepin

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For detailed information about Lactocepin, go to the full flat file.

Reaction

Endopeptidase activity with very broad specificity, although some subsite preferences have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position. Best known for its action on caseins, although it has been shown to hydrolyse hemoglobin and oxidized insulin B chain =

Synonyms

cell envelope associated proteinase, cell envelope proteinase, cell wall anchored proteinase, Cell wall-associated serine proteinase, cell-bound cell envelope proteinase, Cell-envelope proteinase, Cell-envelope-located serine proteinase, Cell-wall-bound proteinase, CEP, Extracellular lactococcal proteinase, Lactocepin, Lactocepin I, lactococcal cell envelope proteinase, Lactococcal cell envelope-associated proteinase, Lactococcal cell wall-associated proteinase, Lactococcal PI-type proteinase, Lactococcal PIII-type poteinase, Lactococcal proteinase, Lactococcal proteinase PI, LP151, PrtH, PrtH2, PrtP, PrtP proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.96 Lactocepin

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Results	in table
373	AA Sequence
10	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
29	Inhibitors
28	Localization
8	Metals/Ions
14	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
76	Organism
7	pH Optimum
3	pH Range
8	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
155	Substrates and Products (Substrate)
16	Subunits
41	Synonyms
5	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]

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Cloned on EC 3.4.21.96 - Lactocepin

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

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Lactococcus lactis

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29885, 29889

recombinant MG 1363 strains containg plasmid-located hybrid proteinase genes constructed from SK11 and Wg2

Lactococcus lactis

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649349

stain SK11, cloned in Lactococcus lactis strains MG1363 and SK1128

Lactococcus lactis

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29891

subsp. lactis MG611, carrying the genes prtP and prtM of subsp. cremoris Wg2 on its chromosome

Lactococcus lactis

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29884

the enzyme of subsp. cremoris WG2 and strain SK11 are plasmid-encoded, the enzyme of subsp. cremoris BC101 is chromosomally -encoded

Lactococcus lactis

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29888