3.4.19.5: beta-aspartyl-peptidase
This is an abbreviated version!
For detailed information about beta-aspartyl-peptidase, go to the full flat file.
Word Map on EC 3.4.19.5
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3.4.19.5
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asrgl1s
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asparaginases
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plant-type
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autoproteolytic
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circularly
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acylases
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autoprocessing
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glycosylasparaginases
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dihydroorotases
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medicine
- 3.4.19.5
- asrgl1s
- asparaginases
-
plant-type
-
autoproteolytic
-
circularly
- acylases
-
autoprocessing
- glycosylasparaginases
- dihydroorotases
- medicine
Reaction
Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide =
Synonyms
ASNase3, asparaginase, asparaginase-like protein 1, asparagine beta-amidohydrolase, ASRGL1, beta-aspartyl dipeptidase, beta-aspartyl peptidase, CpsIadA, dipeptidase, beta-aspartyl, EC 3.4.13.10, EcAIII, hASRGL1, IAD, isoaspartyl aminopeptidase, isoaspartyl aminopeptidase/asparaginase, isoaspartyl dipeptidase, isoaspartyl peptidase, isoaspartyl peptidase/L-asparaginase, LlA, Ntn-hydrolase, potassium-independent asparaginase
ECTree
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Substrates Products
Substrates Products on EC 3.4.19.5 - beta-aspartyl-peptidase
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REACTION DIAGRAM
Asp-Gly-Ala + H2O
Asp + Gly-Ala
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55% of the activity with beta-aspartylglycine
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?
Asp-Gly-Val + H2O
Asp + Gly-Val
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13% of the activity with beta-aspartylglycine
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?
beta-Asp-Gly-Gly + H2O
Asp + Gly-Gly
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95% of the activity with beta-aspartylglycine
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?
beta-Asp-Ile + H2O
Asp + Ile
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37% of the activity with beta-aspartylglycine
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?
beta-Asp-Met + H2O
Asp + Met
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82% of the activity with beta-aspartylglycine
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?
beta-Asp-Thr + H2O
Asp + Thr
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29% of the activity with beta-aspartylglycine
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?
beta-Asp-Val + H2O
Asp + Val
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28% of the activity with beta-aspartylglycine
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?
L-aspartic acid beta-(7-amido-4-methylcoumarin) + H2O
L-aspartic acid + 7-amino-4-methylcoumarin
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-
-
?
beta-Asp-Ala + H2O
Asp + Ala
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51% of the activity with beta-aspartylglycine
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?
beta-Asp-Leu + H2O
Asp + Leu
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59-65% of the activity with beta-aspartylglycine
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?
beta-Asp-Ser + H2O
Asp + Ser
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47-56% of the activity with beta-aspartylglycine
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?
?
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enzyme additionally acts as an asparaginase, EC 3.5.1.1
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-
?
additional information
?
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little or no activity towards L-isoaspartyl-glycine or L-isoaspartyl-L-histidine, gamma-L-glutamyl-L-leucine, gamma-L-glutamyl-glycine, gamma-L-glutamyl-L-cysteine, gamma-L-glutamyl-L-histidine
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-
?
additional information
?
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does not appear to be involved in glutathione metabolism
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-
?
additional information
?
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energetics of isoaspartyl dipeptidase reaction. Dispersion is included in the modeling of the enzymatic reaction
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-
?
additional information
?
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energetics of isoaspartyl dipeptidase reaction. Dispersion is included in the modeling of the enzymatic reaction
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?
additional information
?
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the enzyme shows both isoaspartyl dipeptidase and L-asparaginase activities. Identification of Thr193 in enzyme LlA as the catalytic nucleophile and classification of the enzyme as Ntn-hydrolase
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-
?
additional information
?
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the enzyme shows both isoaspartyl dipeptidase and L-asparaginase activities. Identification of Thr193 in enzyme LlA as the catalytic nucleophile and classification of the enzyme as Ntn-hydrolase
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-
?
additional information
?
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no activity with L-glutamine, L-asparagine amide, L-aspartic acid amide, glycyl-L-asparagine, and N4-(beta-N-acetylglucosaminyl)-L-asparagine
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?
additional information
?
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no activity with L-glutamine, L-asparagine amide, L-aspartic acid amide, glycyl-L-asparagine, and N4-(beta-N-acetylglucosaminyl)-L-asparagine
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-
?