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3.4.19.15: desampylase

This is an abbreviated version!
For detailed information about desampylase, go to the full flat file.

Word Map on EC 3.4.19.15

Reaction

an N6-[small archaeal modifier protein]-[protein]-L-lysine
+
H2O
=
a [protein]-L-lysine
 +
a small archaeal modifier protein

Synonyms

EC 3.4.24.88, HvJAMM1, HVO_2505, JAMM protease, JAMM1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.15 desampylase

Engineering

Engineering on EC 3.4.19.15 - desampylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D101E
mutation does not significantly alter the Zn2+ content of the enzyme, inactive in cleavage of SAMP2 conjugates
D31S
inactive mutant enzyme
H88N
the mol Zn2+/mol of protein content from nearly 1 in wild type is reduced to less than 0.05 in the variant protein
H90Q
the mol Zn2+/mol of protein content from nearly 1 in wild type is reduced to less than 0.05 in the variant protein
S98A
mutant enzyme is significantly reduced in Zn2+ content
D101E
-
mutation does not significantly alter the Zn2+ content of the enzyme, inactive in cleavage of SAMP2 conjugates
-
D31S
-
inactive mutant enzyme
-
H88N
-
the mol Zn2+/mol of protein content from nearly 1 in wild type is reduced to less than 0.05 in the variant protein
-
H90Q
-
the mol Zn2+/mol of protein content from nearly 1 in wild type is reduced to less than 0.05 in the variant protein
-
S98A
-
mutant enzyme is significantly reduced in Zn2+ content
-