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3.4.17.16: membrane Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about membrane Pro-Xaa carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.17.16

Reaction

Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond =

Synonyms

Carboxypeptidase P, CPP, exo-type carboxypeptidase P, membrane Pro-Xaa carboxypeptidase, Microsomal carboxypeptidase, PRCP, prolyl-carboxypeptidase, prolylcarboxypeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.16 membrane Pro-Xaa carboxypeptidase

Disease

topprint

Disease on EC 3.4.17.16 - membrane Pro-Xaa carboxypeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Angioedema
Lisinopril-Induced Angioedema in a Patient with Plasma Prekallikrein Deficiency.
Breast Neoplasms
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells.
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Diabetes Mellitus
Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction.
Essential Hypertension
Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population.
Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.
Hypertension
Expression, purification and crystallization of human prolylcarboxypeptidase.
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.
Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
membrane pro-xaa carboxypeptidase deficiency
Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II.
Obesity
Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
Expression, purification and crystallization of human prolylcarboxypeptidase.
Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction.
Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment.
Prolylcarboxypeptidase gene expression in the heart and kidney: Effects of obesity and diabetes.
Pre-Eclampsia
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia.
Thrombosis
Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
Prolylcarboxypeptidase promotes angiogenesis and vascular repair.