3.4.17.16: membrane Pro-Xaa carboxypeptidase
This is an abbreviated version!
For detailed information about membrane Pro-Xaa carboxypeptidase, go to the full flat file.
Word Map on EC 3.4.17.16
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3.4.17.16
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angiotensin
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bradykinin
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prekallikrein
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kallikrein
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kininogen
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kallikrein-kinin
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angiotensinase
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medicine
- 3.4.17.16
- angiotensin
- bradykinin
- prekallikrein
- kallikrein
- kininogen
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kallikrein-kinin
- angiotensinase
- medicine
Reaction
Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond =
Synonyms
Carboxypeptidase P, CPP, exo-type carboxypeptidase P, membrane Pro-Xaa carboxypeptidase, Microsomal carboxypeptidase, PRCP, prolyl-carboxypeptidase, prolylcarboxypeptidase
ECTree
3.4.17.16 membrane Pro-Xaa carboxypeptidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.17.16 - membrane Pro-Xaa carboxypeptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro-Ala + H2O
Benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro + Ala
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?
Benzyloxycarbonyl-Leu-Gly-Pro-Ala + H2O
Benzyloxycarbonyl-Leu-Gly-Pro + Ala
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?
hirudin variant 3 + H2O
?
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HPLC-ESI-ITMS is used as atool to confirm the C-terminal sequence of HV3, the degradation of the C-terminal of HV3 is studied using carboxypeptidase P und Y
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?
prekallikrein + H2O
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the potential PRCP cleavage site on prekallikrein is identified based on molecular modelling
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?
additional information
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peptides free of proline are also cleaved, but normally at a rather low rate
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?
