3.4.13.21: dipeptidase E

This is an abbreviated version!
For detailed information about dipeptidase E, go to the full flat file.

Reaction

dipeptidase E catalyses the hydrolysis of dipeptides Asp-/-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides =

Synonyms

alpha-aspartyl dipeptidase, Asp-specific dipeptidase, aspartyl dipeptidase, dipeptidase E, PepE, PepE gene product, Salmonella typhimurium, peptidase E

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.21 dipeptidase E

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Results	in table
2909	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
3	Crystallization (Commentary)
6	Inhibitors
3	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
26	Organism
6	PDB ID
12	pH Optimum
1	pH Range
6	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
26	Reference
3	Specific Activity [micromol/min/mg]
40	Substrates and Products (Substrate)
1	Subunits
24	Synonyms
9	Temperature Optimum [°C]
1	Temperature Stability [°C]
3	Turnover Number [1/s]

Inhibitors

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of the Enzyme Summary Page.

Inhibitors on EC 3.4.13.21 - dipeptidase E

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

beta-Alanine

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

137205

iodoacetate

Salmonella enterica subsp. enterica serovar Typhimurium

-

inhibition of wild-type but not of S120C mutant

137203

L-Asp

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

137205

N-ethylmaleimide

Salmonella enterica subsp. enterica serovar Typhimurium

-

inhibition of wild-type but not of S120C mutant

137203

trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

Salmonella enterica subsp. enterica serovar Typhimurium

-

i.e. E-64, inhibition of wild-type but not of S120C mutant

137203

additional information

Salmonella enterica subsp. enterica serovar Typhimurium

-

not inhibited by EDTA, dipicolinic acid, DL-2-amino-2-methylpropanoate

137205

-