3.4.11.B4: Pyrococcus horikoshii deblocking aminopeptidase

This is an abbreviated version, for detailed information about Pyrococcus horikoshii deblocking aminopeptidase, go to the full flat file.

Reaction

The enzyme exhibits aminopeptidase activity and with lower efficiency deblocking activity (i.e. hydrolysis of acetylated amino acids from the N-terminus of peptides). The turnover number with Ac-Ala-Ala-Ala is 260-540fold lower compared to the activity with Ala-Ala-Ala. The turnover number with Ac-Ala-Ala is 350fold lower compared to the activity with Ala-Ala. Low hydrolytic activity for peptide substrates longer than 10 residues. The enzyme is activated by Co2+ or Zn2+. Contains 1.32 mol of Ca2+ per mol of monomer. =

Synonyms

DAP1, DAP2, DAP3, DAPPh, DAPPh2, DAPPh3, deblocking aminopeptidase, PH0519, PH1527, PH1821

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.B4 Pyrococcus horikoshii deblocking aminopeptidase

Sequence

Sequence on EC 3.4.11.B4 - Pyrococcus horikoshii deblocking aminopeptidase

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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
O58255_PYRHO
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
332
36924
TrEMBL
TET_PYRHO
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
353
39014
Swiss-Prot
O59485_PYRHO
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
354
39008
TrEMBL