3.3.2.7: hepoxilin-epoxide hydrolase

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Word Map on EC 3.3.2.7

3.3.2.7

trioxilin

arachidonic

leukotriene

equatorial

fructose-6-phosphate

trihydroxy

glucosamine

glucosamine-6-phosphate

nomenclature

6-phosphate

oscillations

Reaction

(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate

(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate

Synonyms

HEH, hepoxilin epoxide hydrolase, HX epoxide hydrolase, hydrolase, hepoxilin epoxide

ECTree

3 Hydrolases

3.3 Acting on ether bonds

3.3.2 Ether hydrolases

3.3.2.7 hepoxilin-epoxide hydrolase

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Systematic Name on EC 3.3.2.7 - hepoxilin-epoxide hydrolase

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(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase

Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].