Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.3.2.7: hepoxilin-epoxide hydrolase

This is an abbreviated version!
For detailed information about hepoxilin-epoxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.7

Reaction

(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
+
H2O
=
(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate

Synonyms

HEH, hepoxilin epoxide hydrolase, HX epoxide hydrolase, hydrolase, hepoxilin epoxide

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.7 hepoxilin-epoxide hydrolase

General Information

General Information on EC 3.3.2.7 - hepoxilin-epoxide hydrolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
hepoxilins (HXs) and trioxilins (TrXs) are involved in physiological processes such as inflammation, insulin secretion and pain perception in human. They are metabolites of polyunsaturated fatty acids (PUFAs), including arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid, formed by 12-lipoxygenase (LOX) and epoxide hydrolase (EH) expressed by mammalian cells. Hepoxilin epoxide hydrolase converts hepoxilins into trioxilins through hydrolysis of the epoxy group