3.2.2.28: double-stranded uracil-DNA glycosylase

This is an abbreviated version!
For detailed information about double-stranded uracil-DNA glycosylase, go to the full flat file.

Word Map on EC 3.2.2.28

3.2.2.28

thymine

mispairs

guanine

deamination

cytosine

thymine-dna

glycosylases

pyrimidine

etheno

purine

3,n4-ethenocytosine

thermus

adducts

thermophilus

single-stranded

dutp

exocyclic

n2,3-ethenoguanine

Reaction

Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil =

Synonyms

double stranded DNA specific UDG, double-strand uracil-DNA glycosylase, double-stranded uracil-DNA glycosylase, dsDNA specific UDG, dsUDG, Dug, family 5 UDGb, family 5 uracil DNA glycosylase, G:T/U mismatch-specific DNA glycosylase, More, MUG, UDG, UdgB, uracil DNA glycosylase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.28 double-stranded uracil-DNA glycosylase

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Results	in table
1	Activating Compound
2025	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
2	Crystallization (Commentary)
4	Inhibitors
2	KM Value [mM]
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
11	Organism
1	pH Optimum
12	Protein Variants
6	Purification (Commentary)
1	Reaction
11	Reference
1	Source Tissue
25	Substrates and Products (Substrate)
26	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 3.2.2.28 - double-stranded uracil-DNA glycosylase

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D75A

Thermus thermophilus

Q5SJ65

the mutant loses xanthine DNA glycosylase activity while retaining partial uracil and hypoxanthine DNA glycosylase activity

732137

D75N

Thermus thermophilus

Q5SJ65

the mutant loses xanthine DNA glycosylase activity while retaining much of their uracil and hypoxanthine DNA glycosylase activity

732137

D75Q

Thermus thermophilus

Q5SJ65

the mutant loses xanthine DNA glycosylase activity while retaining much of their uracil and hypoxanthine DNA glycosylase activity

H190A

inactive

N120A

the mutant loses xanthine DNA glycosylase activity while retaining partial uracil and hypoxanthine DNA glycosylase activity

732137

D75A

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

the mutant loses xanthine DNA glycosylase activity while retaining partial uracil and hypoxanthine DNA glycosylase activity

D75N

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

the mutant loses xanthine DNA glycosylase activity while retaining much of their uracil and hypoxanthine DNA glycosylase activity

D75Q

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

the mutant loses xanthine DNA glycosylase activity while retaining much of their uracil and hypoxanthine DNA glycosylase activity

H190A

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

inactive

N120A

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

the mutant loses xanthine DNA glycosylase activity while retaining partial uracil and hypoxanthine DNA glycosylase activity

additional information

2 entries