3.2.2.28: double-stranded uracil-DNA glycosylase

This is an abbreviated version!
For detailed information about double-stranded uracil-DNA glycosylase, go to the full flat file.

Reaction

Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil =

Synonyms

double stranded DNA specific UDG, double-strand uracil-DNA glycosylase, double-stranded uracil-DNA glycosylase, dsDNA specific UDG, dsUDG, Dug, family 5 UDGb, family 5 uracil DNA glycosylase, G:T/U mismatch-specific DNA glycosylase, More, MUG, UDG, UdgB, uracil DNA glycosylase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.28 double-stranded uracil-DNA glycosylase

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Results	in table
1	Activating Compound
2025	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
2	Crystallization (Commentary)
4	Inhibitors
2	KM Value [mM]
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
11	Organism
1	pH Optimum
12	Protein Variants
6	Purification (Commentary)
1	Reaction
11	Reference
1	Source Tissue
25	Substrates and Products (Substrate)
26	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Purification

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Purification on EC 3.2.2.28 - double-stranded uracil-DNA glycosylase

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Escherichia coli

P0A9H1

691667, 692966, 694210

HiTrap chelating column chromatography

Thermus thermophilus

Q5SJ65

732137

native and recombinant protein

Escherichia coli

-

690873

recombinant His6-tagged wild-type and mutant enzymes from Escherichia coli strains by nickel affinity chromatography

Mycobacterium tuberculosis

A5U6Y7

679463