3.2.1.167: baicalin-beta-D-glucuronidase

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For detailed information about baicalin-beta-D-glucuronidase, go to the full flat file.

Reaction

Synonyms

baicalin-beta-D-glucuronidase, baicalinase, beta-glucuronidase, EC 3.2.1.31, GUS, HP-GUS, LcGUS30, sGUS

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.167 baicalin-beta-D-glucuronidase

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Results	in table
1	Activating Compound
2	AA Sequence
3	Application
3	Cloned(Commentary)
2	Expression
6	General Information
2	General Stability
13	Inhibitors
10	kcat/KM [mM/s]
15	KM Value [mM]
1	Localization
3	Metals/Ions
10	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
17	Organism
3	Pathway
11	pH Optimum
4	pH Range
9	pH Stability
4	pI Value
5	Protein Variants
7	Purification (Commentary)
1	Reaction
16	Reference
11	Source Tissue
7	Specific Activity [micromol/min/mg]
9	Storage Stability
48	Substrates and Products (Substrate)
10	Subunits
23	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
9	Turnover Number [1/s]

General Information

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General Information on EC 3.2.1.167 - baicalin-beta-D-glucuronidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

2 entries

metabolism

Scutellaria baicalensis

Q9LRC8

the central precursor metabolite of wogonin and baicalein and their glycosylated forms is chrysin

753230

physiological function

3 entries

evolution

Levilactobacillus brevis

-

the enzyme belongs to the glycoside hydrolase family 30, GH30, subfamily 3

731207

evolution

Levilactobacillus brevis FERM BP-4693

-

the enzyme belongs to the glycoside hydrolase family 30, GH30, subfamily 3

-

physiological function

Scutellaria baicalensis

Q9LRC8

relationship between contents of principal flavones in hairy roots of Scutellaria baicalensis with the activity of the beta-glucuronidase (sGUS) enzyme during a culturing cycle. The enzyme activity is characterized by significant and reasonable correlation only with the wogonin contents. The endogenous beta-glucuronidase (sGUS), that catalyzes the cleavage of the glucuronic acid residue from the glycosylated forms of phenolic compounds

753230

physiological function

Scutellaria baicalensis

Q9LRC8

the beta-glucuronidase enzyme is involved in the formation of the more active aglycone flavones in the mdicinal plant. The enzyme activity is characterized by significant correlation only with the wogonin contents, whereas the correlation for the baicalin is insignificant

753230

physiological function

Mus musculus

-

the protective effect of baicalin (the main active compound in Scutellariae radix (Huangqin)) against aminoacetophen (APAP or paracetamol)-induced hepatotoxicity is not altered through enzyme inhibition by D-saccharic acid 1.4-lactone. SAL, a beta-glucuronidase inhibitor, strongly decreased the intestinal beta-glucuronidase activity in mice, but the baicalin-provided protection against APAP-induced cytotoxicity in L-02 cells is not altered after the application of SAL, thus protection of baicalin against APAP-induced hepatotoxicity does not require the conversion into its aglycone baicalein

752730