3.2.1.124: 3-deoxy-2-octulosonidase
This is an abbreviated version!
For detailed information about 3-deoxy-2-octulosonidase, go to the full flat file.
Word Map on EC 3.2.1.124
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3.2.1.124
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lipopolysaccharide
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lps
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tularensis
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helicobacter
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francisella
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pylori
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disaccharide
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subsp
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glucosamine
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kdo-lipid
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novicida
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eight-carbon
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o-antigen
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oligosaccharide
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two-component
- 3.2.1.124
- lipopolysaccharide
- lps
- tularensis
- helicobacter
- francisella
- pylori
- disaccharide
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subsp
- glucosamine
-
kdo-lipid
- novicida
-
eight-carbon
-
o-antigen
- oligosaccharide
-
two-component
Reaction
Synonyms
3-deoxy-D-manno-octulosonic acid hydrolase, Hp0580, hydrolase, 2-keto-3-deoxyoctonate, KdhAB, Kdo hydrolase, octulofuranosylono hydrolase, octulopyranosylonohydrolase, octulosylono hydrolase
ECTree
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General Information
General Information on EC 3.2.1.124 - 3-deoxy-2-octulosonidase
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malfunction
physiological function
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inactivation of Kdo hydrolase activity produces two phenotypes associated with cationic antimicrobial peptide resistance and O-antigen expression. Kdo hydrolase mutants are highly sensitive to polymyxin B. Production of a fully extended O-antigen is also diminished in a Kdo hydrolase mutant, with a consequent increase in core-lipid A
malfunction
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immunization of mice with the kdhAB-deficient mutant provides significant protection against fully virulent Francisella tularensis type A strain Schu S4
malfunction
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immunization of mice with the kdhAB-deficient mutant provides significant protection against fully virulent Francisella tularensis type A strain Schu S4
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Kdo hydrolase plays a role in the maintenance of the bacterial surface. Kdo hydrolase activity modulates O-antigen expression
physiological function
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the enzyme is involved in the virulence of Francisella tularensis strain LVS
physiological function
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the enzyme is involved in the virulence of Francisella tularensis strain LVS
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