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3.2.1.105: 3alpha(S)-strictosidine beta-glucosidase

This is an abbreviated version!
For detailed information about 3alpha(S)-strictosidine beta-glucosidase, go to the full flat file.

Word Map on EC 3.2.1.105

Reaction

strictosidine
+
H2O
=
D-glucose
 +
strictosidine aglycone

Synonyms

glucosidase, strictosidine beta-, ORCA3, SBG, SG, SGD, strictosidine beta-D-glucohydrolase, strictosidine beta-D-glucosidase, strictosidine beta-glucosidase, strictosidine glucosidase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.105 3alpha(S)-strictosidine beta-glucosidase

Application

Application on EC 3.2.1.105 - 3alpha(S)-strictosidine beta-glucosidase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
plays central role in indole alkaloid biosynthesis
pharmacology
Catharanthus roseus produces many pharmaceutically important terpenoid indole alkaloids (TIAs) such as vinblastine, vincristine, ajmalicine, and serpentine. Transcriptional regulator ORCA3 and strictosidine glucosidase (SGD) are both engineered in hairy roots under the control of a glucocorticoid-inducible promoter. Co-overexpression of ORCA3 and SGD result in a significant increase in serpentine by 44%, ajmalicine by 32%, catharanthine by 38%, tabersonine by 40%, lochnericine by 60% and hörhammericine by 56% . The total alkaloid pool is increased significantly by 47%. Combining overexpression of a positive regulator and a pathway gene which is not controlled by this regulator provides a way to enhance alkaloid production