Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.63: methylated-DNA-[protein]-cysteine S-methyltransferase

This is an abbreviated version!
For detailed information about methylated-DNA-[protein]-cysteine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.63

Reaction

DNA (containing 4-O-methylthymine)
+
protein L-cysteine
=
DNA (without 4-O-methylthymine)
 +
protein S-methyl-L-cysteine

Synonyms

Ada protein, Ada-C, AGAT, AGT, AGTendoV, alkylated DNA-protein alkyltransferase, alkylguanine transferase, ATASE, C-hAGT, carboxyl terminal domain of the inducible Escherichia coli ada alkyltransferase, hAGT, methylated-DNA-[protein]-cysteine S-methyltransferase, methylguanine DNA methyltransferase, MGMT, Mgt1, MJ1529, N-hAGT, O6-alkylguanine DNA alkyltransferase, O6-alkylguanine DNA-alkyltransferase, O6-alkylguanine-DNA alkyl-transferase, O6-alkylguanine-DNA alkyltransferase, O6-methylguanine DNA methyltransferase, O6-methylguanine methyltransferase, O6-methylguanine-DNA methyltransferase, O6-methylguanine-DNA-methyltransferase, O6-MGMT, O6meG-DNA alkyltransferase, OGT, Pk-MGMT, SSO2487, Tk-MGMT, TTHA1564

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase

Expression

Expression on EC 2.1.1.63 - methylated-DNA-[protein]-cysteine S-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a loss of MGMT expression is noted in 20 cases of 60 total soft tissue sarcomas
-
ependymomas lack MGMT promoter hypermethylation and show high MGMT protein expression
-
extensive methylation of MGMT promoter is associated with loss/reduced protein expression, methylation of MGMT promoter region is essential for methylation-induced silencing of this gene
-
interleukin-24 down-regulates O6-methylguanine-DNA methyltransferase in melanoma cells, accumulation of functional p53 is essential for interleukin-24-induced down-regulation of O6-methylguanine-DNA methyltransferase
-
MGMT activity is significantly higher in the group with the lowest consumption of vegetables than in the group with the greatest vegetable consumption
-
microRNA-603 directly interacts with the 3'-UTR region of enzyme gene and produces a 6fold decrease of both enzyme mRNA and protein upon transfection in glioblastoma cell line in vitro. Downregulation of enzyme expression by microRNA-181d and microRNA-767-3p is due to degradation of the enzyme mRNA. microRNA-221 and microRNA-222 also downregulate the enzyme expression
-
neither short-term (24 h) nor long-term changes (7 weeks) in S-adenosyl-L-methionine/S-adenosylhomocysteine ratio alter global or MGMT promoter methylation, however, experimentally elevated S-adenosylhomocysteine levels significantly decrease MGMT mRNA levels by more than 50%
-
promoter methylation of O6-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53
-
resistance to alkylating agents such as temozolomide correlates with increased expression of O6-methylguanine-DNA methyltransferase
-
there is a good correlation between the increasing MGMT promoter methylation and decreased MGMT expression, in most patients who has been treated with temozolomide, there is decreased MGMT expression in the post treatment sample when compared to the primary sample
-
treatment with 0.05 mM disulfiram reduces enzyme protein expression
-