2.1.1.63: methylated-DNA-[protein]-cysteine S-methyltransferase
This is an abbreviated version!
For detailed information about methylated-DNA-[protein]-cysteine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.63
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2.1.1.63
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glioblastoma
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temozolomide
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glioma
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o6-benzylguanine
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adduct
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resect
-
hypermethylation
-
methylation-specific
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radiotherapy
-
unmethylated
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mismatch
-
nitrosoureas
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isocitrate
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cpg
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n-methyl-n'-nitro-n-nitrosoguanidine
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multiforme
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chloroethylnitrosoureas
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progression-free
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1,3-bis2-chloroethyl-1-nitrosourea
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chloroethylating
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n-methyl-n-nitrosourea
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astrocytomas
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carmustine
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o6-meg
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interstrand
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glycosylase
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dna-repair
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anaplastic
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karnofsky
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dacarbazine
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repair-deficient
-
tmz-induced
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methylnitrosourea
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phosphotriester
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n-nitroso
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myelosuppression
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chemoradiotherapy
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oligodendrogliomas
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tmz-resistant
-
medicine
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procarbazine
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p14arf
-
drug development
-
diagnostics
-
lomustine
-
miscoding
-
idh-mutant
-
analysis
-
idh-wildtype
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dna-alkylating
-
repair-proficient
-
neuro-oncology
-
premutagenic
-
codeletion
-
molecular biology
- 2.1.1.63
- glioblastoma
- temozolomide
- glioma
- o6-benzylguanine
- adduct
-
resect
-
hypermethylation
-
methylation-specific
-
radiotherapy
-
unmethylated
- mismatch
-
nitrosoureas
- isocitrate
- cpg
- n-methyl-n'-nitro-n-nitrosoguanidine
- multiforme
-
chloroethylnitrosoureas
-
progression-free
-
1,3-bis2-chloroethyl-1-nitrosourea
-
chloroethylating
- n-methyl-n-nitrosourea
- astrocytomas
- carmustine
-
o6-meg
-
interstrand
- glycosylase
-
dna-repair
-
anaplastic
-
karnofsky
- dacarbazine
-
repair-deficient
-
tmz-induced
-
methylnitrosourea
-
phosphotriester
-
n-nitroso
-
myelosuppression
-
chemoradiotherapy
- oligodendrogliomas
-
tmz-resistant
- medicine
- procarbazine
-
p14arf
- drug development
- diagnostics
-
lomustine
-
miscoding
-
idh-mutant
- analysis
-
idh-wildtype
-
dna-alkylating
-
repair-proficient
-
neuro-oncology
-
premutagenic
-
codeletion
- molecular biology
Reaction
Synonyms
Ada protein, Ada-C, AGAT, AGT, AGTendoV, alkylated DNA-protein alkyltransferase, alkylguanine transferase, ATASE, C-hAGT, carboxyl terminal domain of the inducible Escherichia coli ada alkyltransferase, hAGT, methylated-DNA-[protein]-cysteine S-methyltransferase, methylguanine DNA methyltransferase, MGMT, Mgt1, MJ1529, N-hAGT, O6-alkylguanine DNA alkyltransferase, O6-alkylguanine DNA-alkyltransferase, O6-alkylguanine-DNA alkyl-transferase, O6-alkylguanine-DNA alkyltransferase, O6-methylguanine DNA methyltransferase, O6-methylguanine methyltransferase, O6-methylguanine-DNA methyltransferase, O6-methylguanine-DNA-methyltransferase, O6-MGMT, O6meG-DNA alkyltransferase, OGT, Pk-MGMT, SSO2487, Tk-MGMT, TTHA1564
ECTree
2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.63 - methylated-DNA-[protein]-cysteine S-methyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA (containing 6-O-carboxymethylguanine) + protein L-cysteine
DNA (without 6-O-carboxymethylguanine) + protein S-carboxymethyl-L-cysteine
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-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (lacking 6-O-methylguanine) + protein S-methyl-L-cysteine
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
DNA (containing O6-chloroethylguanine) + protein L-cysteine
DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine
-
-
-
-
?
DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine
DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine
-
-
-
-
?
DNA containing 4-O-methylthymine + [protein-L-cysteine
DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (lacking 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (lacking 6-O-methylguanine) + protein S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
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the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
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-
ir
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
-
the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
-
-
ir
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
-
the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
-
-
ir
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
-
the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
-
-
?
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
-
the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
-
-
ir
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
-
the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
-
-
ir
DNA (containing 6-O-methylguanine) + [protein] L-cysteine
DNA (without 6-O-methylguanine) + [protein] S-methyl-L-cysteine
-
the DNA repair protein O6-alkylguanine-DNA alkyltransferase is a principal mechanism of cellular resistance to the toxic and mutagenic effects of DNA damage produced by certain monofunctional alkylating agents. ATase operates by the transfer of the offending alkyl groups from the O6 position of guanine and the O4 position of thymine in damaged DNA to a cysteine residue at the active site of the protein. This is an irreversible process that results in the stoichiometric inactivation of the protein
-
-
ir
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
-
-
?
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
-
-
?
DNA containing 4-O-methylthymine + [protein-L-cysteine
DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
enzyme repairs O6-methylguanine lesions in DNA via alkyl transfer action
-
-
?
DNA containing 4-O-methylthymine + [protein-L-cysteine
DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
DNA-repair enzyme
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
DNA-repair protein that protects cells from killing and mutagenesis by alkylating agents
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
DNA-repair protein that protects cells from killing and mutagenesis by alkylating agents
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the enzyme functions in DNA repair by direct dealkylation of mutagenic 6-O-alkylguanine. The protein methylated at Cys69 becomes a transcriptional activator of the genes in the ada regulon, including its own
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
6-O-methylguanine is an important adduct formed by methylating agents, that, if not repaired, can lead to mutations and death. Its repair is carried out by 6-O-methylguanine DNA-methyltransferase. Exposure of E. coli cells to sublethal concentrations of methylating agent triggers the expression of the gene
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
-
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the enzyme repairs DNA by transferring alkyl (R)-adducts from 6-O-alkylguanine in DNA to its own cysteine residue at codon 145
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the enzyme is a critical defense against alkylation-induced mutagenesis and carcinogenesis
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the enzyme repairs mutagenic and carcinogenic 6-O-alkylguanine in DNA
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
DNA hypermethylation and silencing of MGMT are frequent and rather early events in esophageal squamous cell carcinogenesis. Hypermethylation and inactivation of MGMT may be prevented or reversed by dietary polyphenols, (-)-epigallocatechin-3-gallate and genistein, for the prevention of carcinogenesis
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
key enzyme in DNA repair network. Hypermethylation of the CpG island located in the promoter region of MGMT is primarily responsible for the loss of enzyme function in many tumor types. The methylation mediated silencing of MGMT has two consequences for cancer. First, tumors with MGMT methylation have a new mutator phenotype characterized by the generation of transition point mutations in genes involved in cancer etiology, such as the tumor suppressor p53 and the oncogene K-ras. Second, MGMT hypermethylation demonstrates the possibility of pharmacoepigenomics: methylated tumors are more sensitive to the killing effects of alkylating drugs used in chemotherapy
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the protein protects the integrity of the genome, and it also contributes to the resistance of tumors to DNA-alkylating chemotherapeutic agents
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the enzyme repairs mutagenic and carcinogenic 6-O-alkylguanine in DNA
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
the DNA repair enzyme can specifically remove methyl groups from 6-O-methylguanine, which is a major mutagenic and carcinogenic DNA lesion leading to the G-A transition
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
-
-
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
-
-
-
?
