2.1.1.337: reticuline N-methyltransferase
This is an abbreviated version!
For detailed information about reticuline N-methyltransferase, go to the full flat file.
Reaction
Synonyms
NMT3, RNMT
ECTree
2.1.1.337 reticuline N-methyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.337 - reticuline N-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + (S)-coclaurine
2 S-adenosyl-L-homocysteine + (S)-N,N-dimethylcoclaurine
the mutant enzyme G204E produces (S)-N-methylcoclaurine and (S)-N,N-dimethylcoclaurine in a roughly 2:1 ratio
-
-
?
S-adenosyl-L-methionine + (+)-bulbocapnine
S-adenosyl-L-homocysteine + ?
75% substrate conversion
-
-
?
S-adenosyl-L-methionine + (+)-glaucine
S-adenosyl-L-homocysteine + ?
47% substrate conversion
-
-
?
S-adenosyl-L-methionine + (R)-reticuline
S-adenosyl-L-homocysteine + (S)-tembetarine
98% substrate conversion
-
-
?
S-adenosyl-L-methionine + (R,S)-tetrahydropapaverine
S-adenosyl-L-homocysteine + ?
24% substrate conversion
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
S-adenosyl-L-methionine + (S)-corytuberine
S-adenosyl-L-homocysteine + magnoflorine
82% substrate conversion
-
-
?
S-adenosyl-L-methionine + (S)-N-methylcoclaurine
S-adenosyl-L-homocysteine + (S)-N,N-dimethylcoclaurine
-
-
-
?
S-adenosyl-L-methionine + (S)-N-methylcoclaurine
S-adenosyl-L-homocysteine + ?
reaction of EC 2.1.1.140
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
reaction of EC 2.1.1.140
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
the mutant enzyme G204E produces (S)-N-methylcoclaurine and (S)-N,N-dimethylcoclaurine in a roughly 2:1 ratio
-
-
?
S-adenosyl-L-methionine + (S)-reticuline
S-adenosyl-L-homocysteine + (S)-tembetarine
-
-
-
?
S-adenosyl-L-methionine + (S)-reticuline
S-adenosyl-L-homocysteine + (S)-tembetarine
47% substrate conversion
-
-
?
additional information
?
-
RNMT shows a strong preference for substrates with a tertiary amine, although alkaloids containing a secondary amine (e.g. (R,S)-tetrahydropapaverine, (S)-coclaurine) are also accepted as substrates. In the case of substrates with secondary amines, RNMT catalyzes two sequential N-methylations
-
-
?
additional information
?
-
-
RNMT shows a strong preference for substrates with a tertiary amine, although alkaloids containing a secondary amine (e.g. (R,S)-tetrahydropapaverine, (S)-coclaurine) are also accepted as substrates. In the case of substrates with secondary amines, RNMT catalyzes two sequential N-methylations
-
-
?
additional information
?
-
RNMT shows a strong preference for substrates with a tertiary amine, although alkaloids containing a secondary amine (e.g. (R,S)-tetrahydropapaverine) are also accepted as substrates. In the case of substrates with secondary amines, RNMT catalyzes two sequential N-methylations
-
-
?
additional information
?
-
-
RNMT shows a strong preference for substrates with a tertiary amine, although alkaloids containing a secondary amine (e.g. (R,S)-tetrahydropapaverine) are also accepted as substrates. In the case of substrates with secondary amines, RNMT catalyzes two sequential N-methylations
-
-
?
