2.1.1.244: protein N-terminal methyltransferase

This is an abbreviated version!
For detailed information about protein N-terminal methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

alpha-N-methyltransferase, alpha-N-terminal methyltransferase 1, alphaN-methyltransferase, CG1675, dNTMT, EEF1A lysine methyltransferase 1, eEF1A-KMT1, EEF1AKMT1, Efm5, Efm7, elongation factor methyltransferase 7, FEAT, METT11B, METTL11A, METTL11a/C9orf32/Ad-003, METTL13, METTL13/FEAT, N-terminal and lysine methyltransferase, N-terminal methyltransferase, N-terminal methyltransferase 1, N-terminal RCC1 methyltransferase, N-terminal RCC1 methyltransferase 1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, N6AMT2, NMT1, NNT1, NRMT, NRMT1, Ntm1, NTMT1, peptide N-terminal methyltransferase, PrmA, protein methyltransferase, protein N-terminal methyltransferase 1, Rkm2, SS alphaN-methyltransferase, SSMT, TAE1, YBR261C, YBR261C/Tae1, YGR001C, YLR285W

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.244 protein N-terminal methyltransferase

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Results	in table
3	Activating Compound
39	AA Sequence
3	Application
1	CAS Registry Number
12	Cloned(Commentary)
21	Cofactor
8	Crystallization (Commentary)
111	Disease/ Diagnostics
1	Expression
73	General Information
1	General Stability
6	IC50 Value
18	Inhibitors
19	kcat/KM [mM/s]
3	Ki Value [mM]
27	KM Value [mM]
18	Localization
2	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
60	Organism
30	PDB ID
9	pH Optimum
24	Protein Variants
6	Purification (Commentary)
7	Reaction
28	Reference
18	Source Tissue
133	Substrates and Products (Substrate)
5	Subunits
85	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.1.1.244 - protein N-terminal methyltransferase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

GDP

Saccharomyces cerevisiae

P38340, Q05874

methylation of eEF1A is increased in the presence of either GDP or GTP, which are known to bind to eEF1A and to induce conformational changes

756463

GTP

Saccharomyces cerevisiae

P38340, Q05874

methylation of eEF1A is increased in the presence of either GDP or GTP, which are known to bind to eEF1A and to induce conformational changes

756463

additional information

Homo sapiens

Q9BV86

isozyme NRMT2 expression activates isozyme NRMT1 activity, not through priming, but by increasing its stability and substrate affinity. NRMT1 has increased N-terminal trimethylation activity when co-expressed with NRMT2. Catalytic activity of NRMT2 is not necessary for increased trimethylation by NRMT1

758296

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