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Disease on EC 2.1.1.244 - protein N-terminal methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis.
Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.
Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Carcinogenesis
KRAS-Driven Cancers Are Dependent on METTL13-Mediated eEF1A Methylation.
Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis.
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.
Carcinoma
Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3.
METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1? pathway and c-Myc expression.
METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.
Carcinoma, Renal Cell
METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1? pathway and c-Myc expression.
Colorectal Neoplasms
Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.
Deafness
Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.
Dengue
A crystal structure of the Dengue virus NS5 polymerase delineates inter-domain amino acids residues that enhance its thermostability and de novo initiation activities.
Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach.
Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.
Endometrial Neoplasms
Effects of m6A RNA methylation regulators on endometrial cancer.
Gastrointestinal Neoplasms
Kinetic mechanism of protein N-terminal methyltransferase 1.
Lung Neoplasms
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Neoplasm Metastasis
METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1? pathway and c-Myc expression.
METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.
Neoplasms
Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors.
Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis.
Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma.
METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer.
Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.
Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Retinoblastoma
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Squamous Cell Carcinoma of Head and Neck
Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma.
Starvation
CREB-mediated transcriptional activation of NRMT1 drives muscle differentiation.
Urinary Bladder Neoplasms
METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.
Uterine Cervical Neoplasms
Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3.