1.8.5.1: glutathione dehydrogenase (ascorbate)

This is an abbreviated version!
For detailed information about glutathione dehydrogenase (ascorbate), go to the full flat file.

Reaction

2 glutathione +

Synonyms

At1g19570, At1g75270, At5g16710, AtDHAR, AtDHAR1, AtDHAR2, AtDHAR3, CrDHAR1, DasA reductase, dehydroascorbate reductase, dehydroascorbate reductase 2, dehydroascorbic acid reductase, dehydroascorbic reductase, dehydrogenase, glutathione (ascorbate), DHA reductase, DHA-R, DHAR, DHAR1, DHAR2, DHAR3, DHAR3a, DHAR4, DHAR5, dioscorin, GDOR, glutathione dehydroascorbate reductase, glutathione-dependent dehydroascorate reductase, glutathione:dehydroascorbic acid oxidoreductase, GRX1, GRX2, GSH-DHAR, GSH:DHA-oxidoreductase, GSTO, GSTO1, GSTO1-1, GSTO2, GSTO2-2, LcDHAR, metallothionein-1, metallothionein-2, More, MT-I, MT-II, nlGSTO, OsDHAR, OsDHAR1, PbDHAR, PgDHAR1, PtrDHAR1, PtrDHAR2, PtrDHAR3A, PtrDHAR3B, SPD1

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.5 With a quinone or similar compound as acceptor

                1.8.5.1 glutathione dehydrogenase (ascorbate)

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Results	in table
11	Activating Compound
1816	AA Sequence
3	Application
1	CAS Registry Number
42	Cloned(Commentary)
1	Cofactor
14	Crystallization (Commentary)
440	Disease/ Diagnostics
9	Expression
121	General Information
2	General Stability
38	Inhibitors
44	kcat/KM [mM/s]
143	KM Value [mM]
110	Localization
1	Metals/Ions
27	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
141	Organism
5	Pathway
40	PDB ID
33	pH Optimum
18	pH Range
3	pH Stability
4	pI Value
61	Protein Variants
34	Purification (Commentary)
20	Reaction
4	Reaction Type
113	Reference
1	Renatured (Commentary)
129	Source Tissue
39	Specific Activity [micromol/min/mg]
3	Storage Stability
135	Substrates and Products (Substrate)
47	Subunits
315	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
12	Temperature Range [°C]
21	Temperature Stability [°C]
69	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 1.8.5.1 - glutathione dehydrogenase (ascorbate)

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Oryza sativa Japonica Group

Q65XA0

computational modeling analysis is performed to understand the potential of five plant metabolites including ascorbic acid (AA), reduced glutathione (GSH), serotonin, jasmonic acid (JA), and salicylic acid (SA) in ameliorating metal/metalloid stress in rice, using dehydroascorbate reductase (DHAR) as a model. Six metal/metalloid ions (As3+, As5+, Cd2+, Cu2+, Pb2+, Zn2+) are used in the study, and the relative affinity, binding geometry and electrostatic surfaces of secondary metabolites and ions with the active site of DHAR are predicted. The results reveal that all the metabolites and ions may potentially interact with the active catalytic site of DHAR. The free energies of binding (docking score) of the metabolites are manyfolds higher than those of the ions. On comparison, the docking score of As3+ is found to be 28.29% of that of AA. Further, compared to AA, SA has lower score, and GSH, JA and serotonin show 1.42, 1.30 and 1.18fold higher score than AA. Further analysis reveals that the electrostatic surfaces of the metabolites and ions overlap with one another. Statistical analysis is performed to determine the properties of the ligands which are crucial in facilitating interaction of the ligands

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