1.5.1.6: formyltetrahydrofolate dehydrogenase
This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.
Reaction
Synonyms
10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I
ECTree
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Activating Compound
Activating Compound on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase
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4'-phosphopantetheinyl transferase
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4'-phosphopantetheinyl transferase activates dehydrogenase catalysis of ALDH1L2 by modifying Ser375
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C1-tetrahydrofolate synthase
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10-formyltetrahydrofolate synthetase activity of trifunctional enzyme causes together with its substrates MgATP, formate, and tetrahydrofolate an 3fold increase of initial velocity
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serine hydroxymethyltransferase
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addition of SHMT and of its substrate L-serine increases the initial reaction rate by 1.8fold with 10-formyltetrahydropteroylpentaglutamate as substrate, SHMT increases the release of product
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5 to 15 mM: 1.7fold increase in activity, higher concentrations have no further effect, it may reduce oxidized Cys-707 or another important sulfhydryl group
2-mercaptoethanol
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dehydrogenase and hydrolase activities are dependent on the presence of high concentrations of 2-mercaptoethanol to prevent the oxidative degradation of the substrate 10-formyltetrahydrofolate
2-mercaptoethanol
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optimal dehydrogenase activity requires 15 mM or higher concentrations
NADPH
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activates at concentrations and in ratio with NADP+ consistent with those in rat liver in vivo, activation is associated with higher Ki-value for tetrahydrofolate