1.3.1.34: 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]
This is an abbreviated version!
For detailed information about 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing], go to the full flat file.
Word Map on EC 1.3.1.34
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1.3.1.34
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beta-oxidation
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unsaturated
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polyunsaturated
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odd-numbered
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even-numbered
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3-hydroxyacyl-coa
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5.3.3.8
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chain-shortened
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trans-2
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tetradecylthioacetic
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reductase-dependent
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petroselinic
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delta3-delta2-enoyl-coa
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omega-oxidation
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3,delta
- 1.3.1.34
-
beta-oxidation
- unsaturated
-
polyunsaturated
-
odd-numbered
-
even-numbered
- 3-hydroxyacyl-coa
-
5.3.3.8
-
chain-shortened
-
trans-2
-
tetradecylthioacetic
-
reductase-dependent
-
petroselinic
-
delta3-delta2-enoyl-coa
-
omega-oxidation
-
3,delta
Reaction
Synonyms
2,4-dienoyl coenzyme A reductase, 2,4-dienoyl-CoA reductase, 2,4-dienoyl-CoA reductase (NADPH), 2,4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase (NADPH), 4-enoyl-CoA reductase [NADPH], DCR, DECR, FADH, pDCR, peroxisomal 2,4-dienoyl CoA reductase
ECTree
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Engineering
Engineering on EC 1.3.1.34 - 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]
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C337A
the mutation results in the loss of most of the iron and acid-labile sulfur and exhibits 0.09% of wild type activity
Y166F
mutant exhibits 27% of the wild type activity, however, the product of the reduction is 3-enoyl-CoA instead of 2-enoyl-CoA
Y166F/H252A
the double mutation exhibits 4.4% of the wild type activity
D137A
relative activity: 3.32% (substrate: 2,4-decadienoyl CoA), 1.27% (substrate: 2,4-hexadienoyl CoA) (wild-type: 100%)
D155A
relative activity: 36.3% (substrate: 2,4-decadienoyl CoA), 59.6% (substrate: 2,4-hexadienoyl CoA) (wild-type: 100%)
D186A
relative activity: 6.21% (substrate: 2,4-decadienoyl CoA), 1.86% (substrate: 2,4-hexadienoyl CoA) (wild-type: 100%)
D268A
relative activity: 2.75% (substrate: 2,4-decadienoyl CoA), 1.14% (substrate: 2,4-hexadienoyl CoA) (wild-type: 100%)
D86A
relative activity: 1.70% (substrate: 2,4-decadienoyl CoA), 1.76% (substrate: 2,4-hexadienoyl CoA) (wild-type: 100%)
E215A
relative activity: 28.9% (substrate: 2,4-decadienoyl CoA), 7.59% (substrate: 2,4-hexadienoyl CoA) (wild-type: 100%)