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1.21.3.6: aureusidin synthase

This is an abbreviated version!
For detailed information about aureusidin synthase, go to the full flat file.

Word Map on EC 1.21.3.6

Reaction

2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside
+
1/2 O2
=
aureusidin 6-O-beta-D-glucoside
 +
H2O

Synonyms

AmAS1, AS1, aureusidin synthase, aurone synthase, More, synthase, aureusidin

ECTree

     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.3 With oxygen as acceptor
                1.21.3.6 aureusidin synthase

General Information

General Information on EC 1.21.3.6 - aureusidin synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
substrate specificity allows elucidation of a likely mechanism of aurone formation from 2,4,6,4-tetrahydroxychalcone or PHC involving both tyrosinase and catechol oxidase activities of the Antirrhinum majus PPO, pathway overview. Starting with THC, tyrosinase and catechol oxidase activity, EC 1.14.18.1, result in 3-hydroxylation and formation of the corresponding o-quinone. Whether aureusidine synthase PPO carries out the 3-hydroxylation reaction in vivo, or whether a cytochrome P450 chalcone 3-hydroxylase is also involved is not definitively established. Aureusidine synthase likely forms the same quinone from 2',3,4,4',6'-pentahydroxychalcone without the need for the 3-hydroxylation step. The resulting quinone is predicted to undergo a 2-step non-enzyme mediated rearrangement to form aureusidine
physiological function