1.2.1.32: aminomuconate-semialdehyde dehydrogenase

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For detailed information about aminomuconate-semialdehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-aminomuconate semialdehyde dehydrogenase, 2-aminomuconate-6-semialdehyde dehydrogenase, 2-aminomuconic 6-semialdehyde dehydrogenase, 2-AMS dehydrogenase, 2-hydroxy-5-methyl-6-oxohexa-2,4-dienoate dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, 2-hydroxymuconic 6-semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, aldehyde dehydrogenase, ALDH12, Aldh8a1, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, AMDH, aminomuconate semialdehyde dehydrogenase, aminomuconate-semialdehyde dehydrogenase, AMSDH, dehydrogenase, 2-hydroxymuconate semialdehyde, dehydrogenase, aminomuconate semialdehyde, HMSD-2, nbaE

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.32 aminomuconate-semialdehyde dehydrogenase

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Results	in table
1	Activating Compound
339	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
21	Cofactor
1	Crystallization (Commentary)
7	General Information
22	Inhibitors
2	kcat/KM [mM/s]
2	Ki Value [mM]
38	KM Value [mM]
12	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
152	Organism
9	Pathway
2	PDB ID
6	pH Optimum
2	pH Range
1	pI Value
10	Protein Variants
14	Purification (Commentary)
3	Reaction
7	Reaction Type
42	Reference
4	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
127	Substrates and Products (Substrate)
12	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.2.1.32 - aminomuconate-semialdehyde dehydrogenase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

purified recombinant His-tagged E268A mutant enzyme in complex with NAD+ or NAD+ and 2-aminomuconate or 2-hydroxymuconate, hanging drop diffusion, mixing of 0.0015 ml of 40 mg/ml protein solution with 0.0015 ml of reservoir solution containing 20% PEG 3350 and 0.2 M sodium phosphate dibasic monohydrate, pH 9.1, at 18°C, 2-3 days, crystals are soaked in ligand solution for the formation of complex crystals, X-ray diffraction structure determination and analysis at 1.95-2.20 A resolution, molecular replacement using 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase, PDB: 2D4E, as a search model, and molecular modelling

Pseudomonas fluorescens

Q83V33

743338