1.2.1.25: branched-chain alpha-keto acid dehydrogenase system

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For detailed information about branched-chain alpha-keto acid dehydrogenase system, go to the full flat file.

Reaction

Synonyms

2-oxoisovalerate dehydrogenase, alpha-ketoisovalerate dehydrogenase, BCKD, BCKD complex, BCKDalpha, BCKDbeta, BCKDC, BCKDH, BCKDHA, BCKDHB, bkdA, BKDH, branched chain alpha-keto acid dehydrogenase complex, branched chain keto-acid dehydrogenase, branched-chain alpha-keto acid dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase, branched-chain alpha-ketoacid dehydrogenase complex, branched-chain alpha-ketoacid dehydrogenase complex E1alpha subunit, branched-chain ketoacid dehydrogenase, branched-chain-keto-acid dehydrogenase alpha, branched-chain-keto-acid dehydrogenase beta, dehydrogenase, 2-oxoisovalerate (acylating), E1alpha subunit, E1beta subunit, mitochondrial branched-chain keto-acid dehydrogenase, More

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.25 branched-chain alpha-keto acid dehydrogenase system

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Results	in table
2	Activating Compound
14	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
30	Cofactor
114	Disease/ Diagnostics
6	Expression
35	General Information
7	Inhibitors
2	KM Value [mM]
11	Localization
38	Natural Substrates/ Products (Substrates)
188	Organism
12	Pathway
1	pH Optimum
1	pH Range
6	Posttranslational Modification
1	Protein Variants
1	Purification (Commentary)
1	Reaction
4	Reaction Type
17	Reference
56	Source Tissue
41	Substrates and Products (Substrate)
8	Subunits
47	Synonyms
1	Systematic Name

Cloned

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Cloned on EC 1.2.1.25 - branched-chain alpha-keto acid dehydrogenase system

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

gene bkdA, the BKDH complex from Streptomyces avermitilis cannot readily be stably expressed in Escherichia coli. This is mostly due to low yields of active, properly folded enzyme in a complex expression system. Codon optimization, recombinant expression of the enzyme complex in Escherichia coli strain BW25113 by selectively regulating individual subunit gene expression

Streptomyces avermitilis

Q53592

762852

genes BCKDHA and BCKDHB, encoding the subunits BCKDHA and BCKDHB if the E1 component, located on chromosome 19q13.2 and 6q14.1, respectively

Homo sapiens

P12694; P21953

763515

quantitative real-time PCR enzyme expression analysis

Rattus norvegicus

-

763378