1.2.1.19: aminobutyraldehyde dehydrogenase

This is an abbreviated version!
For detailed information about aminobutyraldehyde dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-aminobutanal dehydrogenase, 4-aminobutyraldehyde dehydrogenase, ABAL dehydrogenase, ABALDH, ALDH10A8, ALDH10A9, AMADH, AMADH1, AMADH2, aminoaldehyde dehydrogenase, BADH, betaine aldehyde dehydrogenase, dehydrogenase, aminobutyraldehyde, EC 1.5.1.35, gadbh, gamma-aminobutanal dehydrogenase, gamma-aminobutyraldehyde dehydroganase, gamma-aminobutyraldehyde dehydrogenase, gamma-guanidinobutyraldehyde dehydrogenase, MdAMADH1, MdAMADH2, More, NAD+-aminoaldehyde dehydrogenase, NAD+-dependent aminoaldehyde dehydrogenase, PatD, PsAMADH 1, PsAMADH 2, SlAMADH1, SlAMADH2, YdcW, ZmAMADH1a, ZmAMADH1b, ZmAMADH2

ECTree

     1 Oxidoreductases

         1.2 Acting on the aldehyde or oxo group of donors

             1.2.1 With NAD⁺ or NADP⁺ as acceptor

                1.2.1.19 aminobutyraldehyde dehydrogenase

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Results	in table
2	Activating Compound
3602	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
25	Disease/ Diagnostics
7	Expression
22	General Information
3	General Stability
36	Inhibitors
37	kcat/KM [mM/s]
7	Ki Value [mM]
150	KM Value [mM]
19	Localization
4	Metals/Ions
19	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
63	Organism
12	Pathway
62	PDB ID
26	pH Optimum
10	pH Range
1	pH Stability
2	pI Value
4	Protein Variants
19	Purification (Commentary)
2	Reaction
3	Reaction Type
49	Reference
41	Source Tissue
38	Specific Activity [micromol/min/mg]
5	Storage Stability
199	Substrates and Products (Substrate)
18	Subunits
83	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
23	Temperature Stability [°C]
69	Turnover Number [1/s]

Disease

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Disease on EC 1.2.1.19 - aminobutyraldehyde dehydrogenase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Cardiomegaly

Betaine Aldehyde Dehydrogenase expression during physiological cardiac hypertrophy induced by pregnancy.

28630000

Cataract

Molecular Mimicry between Betaine Aldehyde Dehydrogenase of Leptospira and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients.

31746662

Dehydration

Betaine aldehyde dehydrogenase genes from Arabidopsis with different sub-cellular localization affect stress responses.

21053011

Diabetes Complications

Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase.

12604221

Foot-and-Mouth Disease

Co-ordinate expression of glycine betaine synthesis genes linked by the FMDV 2A region in a single open reading frame in Pichia pastoris.

17955192

Infections

Betaine aldehyde dehydrogenase from Pseudomonas aeruginosa: cloning, over-expression in Escherichia coli, and regulation by choline and salt.

16315011

Infections

Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.

16426571

Infections

Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram.

12604199

Infections

The crystal structure of a ternary complex of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa Provides new insight into the reaction mechanism and shows a novel binding mode of the 2'-phosphate of NADP+ and a novel cation binding site.

19013472

Uveitis

Molecular Mimicry between Betaine Aldehyde Dehydrogenase of Leptospira and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients.

31746662

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