1.14.99.1: prostaglandin-endoperoxide synthase

This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.

Reaction

Synonyms

(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.1 prostaglandin-endoperoxide synthase

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Results	in table
40	Activating Compound
2844	AA Sequence
6	Application
2	CAS Registry Number
27	Cloned(Commentary)
17	Cofactor
3	Crystallization (Commentary)
87524	Disease/ Diagnostics
11	Expression
19	General Information
5	General Stability
34	IC50 Value
221	Inhibitors
3	kcat/KM [mM/s]
5	Ki Value [mM]
101	KM Value [mM]
30	Localization
6	Metals/Ions
17	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
123	Organism
8	Pathway
210	PDB ID
24	pH Optimum
2	pH Range
1	pH Stability
5	Posttranslational Modification
66	Protein Variants
20	Purification (Commentary)
3	Reaction
34	Reaction Type
112	Reference
1	Renatured (Commentary)
121	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
117	Substrates and Products (Substrate)
12	Subunits
216	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.14.99.1 - prostaglandin-endoperoxide synthase

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.0027

Homo sapiens

-

mutant Y348F, cyclooxygenase activity

672161

0.0039

Homo sapiens

-

mutant Y504F, cyclooxygenase activity

672161

0.0047

Homo sapiens

-

mutant Y348F/Y504F, cyclooxygenase activity

672161

0.0058

Homo sapiens

-

wild-type, cyclooxygenase activity

672161

15000

Salvelinus fontinalis

Q9PTN3, Q9PW89

cyclooxygenase activity for partially purified prostaglandin H synthase 2 of Salvelinus fontinalis, tPGHS-2

673508

2.4

Bos taurus

-

prostaglandin H1 synthesis

438375

2300

Salvelinus fontinalis

Q9PTN3, Q9PW89

cyclooxygenase activity for partially purified prostaglandin H synthase 1 of Salvelinus fontinalis, tPGHS-1

673508

4220

Homo sapiens

P23219, P35354

purified recombinant His6-tagged PGHS-2, pH 8.0, 37°C

728736

43

Ovis aries

-

-

438383