1.14.99.1: prostaglandin-endoperoxide synthase
This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.
Word Map on EC 1.14.99.1
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1.14.99.1
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arachidonic
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indomethacin
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necrosis
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nsaid
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tnf
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lipopolysaccharide
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endothelial
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nonsteroidal
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celecoxib
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artery
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thromboxane
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aspirin
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lps
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lipoxygenase
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pain
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cardiovascular
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lps-induced
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platelet
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prostanoids
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agonist
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gastrointestinal
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mapks
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phospholipase
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gastric
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carcinogenesis
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eicosanoids
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leukotriene
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ulcer
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arthritis
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analgesic
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prostacyclin
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nf-kappab
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lps-stimulated
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colorectal
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angiogenesis
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edema
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tnf-alpha
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ibuprofen
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vasodilator
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il-1beta
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osteoarthritis
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nonselective
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factor-alpha
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chemopreventive
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lipopolysaccharide-induced
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factor-kappa
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endothelium-dependent
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vasoconstriction
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l-name
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endothelium-derived
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medicine
- 1.14.99.1
-
arachidonic
- indomethacin
- necrosis
-
nsaid
- tnf
- lipopolysaccharide
- endothelial
-
nonsteroidal
- celecoxib
- artery
-
thromboxane
- aspirin
- lps
- lipoxygenase
- pain
- cardiovascular
-
lps-induced
- platelet
-
prostanoids
- agonist
- gastrointestinal
- mapks
- phospholipase
- gastric
- carcinogenesis
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eicosanoids
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leukotriene
- ulcer
- arthritis
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analgesic
- prostacyclin
- nf-kappab
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lps-stimulated
- colorectal
- angiogenesis
- edema
- tnf-alpha
- ibuprofen
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vasodilator
- il-1beta
- osteoarthritis
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nonselective
- factor-alpha
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chemopreventive
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lipopolysaccharide-induced
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factor-kappa
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endothelium-dependent
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vasoconstriction
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l-name
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endothelium-derived
- medicine
Reaction
Synonyms
(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2
ECTree
1.14.99.1 prostaglandin-endoperoxide synthaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.14.99.1 - prostaglandin-endoperoxide synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
arachidonate + AH2 + 2 O2
prostaglandin G2 + A + ?
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-
-
?
arachidonate + AH2 + 2 O2
prostaglandin H2 + A + H2O
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-
-
?
arachidonate + AH2 + O2
prostaglandin H2 + A + H2O
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-
-
-
?
arachidonate + AH2 + O2
prostaglandin H2 + A + H2O
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-
-
-
?
arachidonate + AH2 + O2
prostaglandin H2 + A + H2O
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-
-
?
arachidonate + reduced acceptor + O2
prostaglandin H2 + acceptor + H2O
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-
-
-
?
arachidonate + reduced acceptor + O2
prostaglandin H2 + acceptor + H2O
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-
-
-
?
arachidonate + reduced acceptor + O2
prostaglandin H2 + acceptor + H2O
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-
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?
arachidonate + reduced acceptor + O2
prostaglandin H2 + acceptor + H2O
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-
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?
additional information
?
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dopamine precursor L-dihydroxyphenylalanine, i.e. L-DOPA, and metabolites dihydroxyphenylacetic acid, homovanillic acid, and 3-methoxytyramine may serve as substrates for prostaglandin H synthase-catalyzed bioactivation to free radical intermediates
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?
additional information
?
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activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha
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?
additional information
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activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha
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?
additional information
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enzyme has a central position in prostanoic metabolism: first step in formation of prostaglandins and thromboxanes, the conversion of arachidonic acid to prostaglandin endoperoxides G and H
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?
additional information
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prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview
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?
additional information
?
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prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview
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?
additional information
?
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prostaglandin synthesis within the fetal central nervous system is critical for the the modulation of hypotension-induced fetal ACTH secretion involving PGHS-2, overview
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?
additional information
?
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the expression of PGHS-2 may be involved in inhibiting progesterone production
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?
