1.14.16.6: mandelate 4-monooxygenase
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For detailed information about mandelate 4-monooxygenase, go to the full flat file.
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Synonyms
L-mandelate-4-hydroxylase, mandelic acid 4-hydroxylase, oxygenase, mandelate 4-mono-
ECTree
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Systematic Name
Systematic Name on EC 1.14.16.6 - mandelate 4-monooxygenase
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(S)-2-hydroxy-2-phenylacetate,tetrahydropteridine:oxygen oxidoreductase (4-hydroxylating)
Requires Fe2+. The enzyme has been characterized from the bacterium Pseudomonas putida. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.