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1.14.16.6: mandelate 4-monooxygenase

This is an abbreviated version!
For detailed information about mandelate 4-monooxygenase, go to the full flat file.

Reaction

(S)-2-Hydroxy-2-phenylacetate
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
(S)-4-hydroxymandelate
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

L-mandelate-4-hydroxylase, mandelic acid 4-hydroxylase, oxygenase, mandelate 4-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.6 mandelate 4-monooxygenase

Inhibitors

Inhibitors on EC 1.14.16.6 - mandelate 4-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
0.5 mM, 88% inhibition
2,2'-bipyridyl
-
0.5 mM, 83% inhibition
2-amino-4-hydroxy-6,7-dimethyl-tetrahydropteridine
-
above 0.000025 mM, slight inhibition
4-hydroxymercuribenzoate
-
partially reversible by thiol compounds
8-hydroxyquinoline
-
0.5 mM, 60% inhibition
Ag2+
-
0.0001 mM, 42% inhibition
amethopterin
-
-
Aminopterine
-
-
Cd2+
-
0.0001 mM, 66% inhibition
Cu2+
-
0.0001 mM, 40% inhibition
diethyldithiocarbamate
-
0.5 mM, 16% inhibition
EDTA
-
0.5 mM, 64% inhibition
guanidine hydrochloride
-
2.0 mM, 95% inhibition
Hg2+
-
0.0001 mM, 56% inhibition
iodoacetamide
-
weak
iodoacetate
-
weak
SDS
-
0.1 mM, complete inhibition
Thiourea
-
1.0 mM, complete inhibition
Urea
-
2.0 mM, complete inhibition