1.14.14.26: 24-hydroxycholesterol 7alpha-hydroxylase
This is an abbreviated version!
For detailed information about 24-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.26
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1.14.14.26
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oxysterols
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cyp7b1
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drug-metabolizing
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pregnane
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docetaxel
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runx2
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androstane
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7alpha-hydroxylated
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sulfotransferase
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pregnenolone
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antiepileptic
- 1.14.14.26
- oxysterols
- cyp7b1
-
drug-metabolizing
-
pregnane
- docetaxel
- runx2
-
androstane
-
7alpha-hydroxylated
-
sulfotransferase
- pregnenolone
-
antiepileptic
Reaction
Synonyms
24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, EC 1.14.13.99, oxysterol 7alpha-hydroxylase CYP39A1
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Systematic Name
Systematic Name on EC 1.14.14.26 - 24-hydroxycholesterol 7alpha-hydroxylase
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(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.