1.14.13.127: 3-(3-hydroxyphenyl)propanoate hydroxylase
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For detailed information about 3-(3-hydroxyphenyl)propanoate hydroxylase, go to the full flat file.
Reaction
Synonyms
3-(3-hydroxyphenyl)propionate hydroxylase, 3HPP 2-hydroxylase, 3HPP hydroxylase, MhpA, MhpAK-12
ECTree
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General Information
General Information on EC 1.14.13.127 - 3-(3-hydroxyphenyl)propanoate hydroxylase
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evolution
malfunction
metabolism
additional information
MhpAK-12 and its putative homologues belong to taxa that are phylogenetically distant from functionally identified FAD-containing monooxygenases (hydroxylases)
evolution
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MhpAK-12 and its putative homologues belong to taxa that are phylogenetically distant from functionally identified FAD-containing monooxygenases (hydroxylases)
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gene deletion and complementation showed that mhpA is vital for its growth on 3-(3-hydroxyphenyl)propanoate (3HPP), but the mhpA deletion strain is still able to grow on 3-(2,3-dihydroxyphenyl)propionate (DHPP), the hydroxylation product is transformed from 3HPP by MhpAK-12. MhpAK-12 has approximately an extra 150 residues at its C-terminus in comparison to its close homologues, but its truncated versions MhpAK-12_400 and MhpAK-12_480 (with 154 and 74 residues deleted from the C-terminus, respectively) both lose their activities
malfunction
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gene deletion and complementation showed that mhpA is vital for its growth on 3-(3-hydroxyphenyl)propanoate (3HPP), but the mhpA deletion strain is still able to grow on 3-(2,3-dihydroxyphenyl)propionate (DHPP), the hydroxylation product is transformed from 3HPP by MhpAK-12. MhpAK-12 has approximately an extra 150 residues at its C-terminus in comparison to its close homologues, but its truncated versions MhpAK-12_400 and MhpAK-12_480 (with 154 and 74 residues deleted from the C-terminus, respectively) both lose their activities
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proposed pathway for 3-(3-hydroxyphenyl)propanoate (3HPP) degradation by Escherichia coli strain K-12 via the meta pathway, together with the catabolic reactions catalyzed by the mhp gene products in vivo, overview
metabolism
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proposed pathway for 3-(3-hydroxyphenyl)propanoate (3HPP) degradation by Escherichia coli strain K-12 via the meta pathway, together with the catabolic reactions catalyzed by the mhp gene products in vivo, overview
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the 154 amino acid residues in the C-terminus of MhpAK-12 play an important role in its hydroxylation activity of the enzyme
additional information
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the 154 amino acid residues in the C-terminus of MhpAK-12 play an important role in its hydroxylation activity of the enzyme
additional information
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the 154 amino acid residues in the C-terminus of MhpAK-12 play an important role in its hydroxylation activity of the enzyme
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