1.1.1.160: dihydrobunolol dehydrogenase

This is an abbreviated version, for detailed information about dihydrobunolol dehydrogenase, go to the full flat file.

Reaction

(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol
+
NADP+
=
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone
+
NADPH
+
H+

Synonyms

bunolol reductase, dehydrogenase, dihydrobunolol

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.160 dihydrobunolol dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.160 - dihydrobunolol dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+
show the reaction diagram
-
i.e. bunolol, r, also acts more slowly with NAD+
i.e. dihydrobunolol
r
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH
?
show the reaction diagram
-
i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver
-
-
-