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Literature summary for 1.1.1.160 extracted from

  • Leinweber, F.J.; Greenough, R.C.; Schwender, C.F.; Kaplan, H.R.; di Carlo, F.J.
    Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol (1972), Xenobiotica, 2, 191-202.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH Homo sapiens i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
-17°C, 4 months, completely stable Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH i.e. bunolol, r, also acts more slowly with NAD+ Homo sapiens (+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ i.e. dihydrobunolol r
(+,-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH i.e. bunolol, metabolism of bunolol, a potent beta-adrenoceptor blocking agent in human liver Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ slow reaction Homo sapiens
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens