1.1.1.147: 16alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 16alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

a 16alpha-hydroxysteroid
+
NAD(P)+
=
a 16-oxosteroid
+
NAD(P)H
+
H+

Synonyms

16alpha-hydroxy steroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.147 16alpha-hydroxysteroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.147 - 16alpha-hydroxysteroid dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
16-ketotestosterone + NAD(P)H
16alpha-hydroxytestosterone + NAD(P)+
show the reaction diagram
-
-
-
r
17alpha-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17alpha-estradiol + NAD(P)+
show the reaction diagram
-
best substrate tested, changing configuration or oxidation state of the neighboring oxygen substituent at C-17 increases the rate of reduction
-
r
17beta-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17beta-estradiol + NAD(P)+
show the reaction diagram
3-hydroxy-estra-1,3,5(10)-triene-16,17-dione + NAD(P)H
3,16alpha-dihydroxy-estra-1,3,5(10)-triene-17-one + NAD(P)H
show the reaction diagram
-
-
-
r
3beta,17beta-dihydroxy-androst-5-en-16-one + NAD(P)H
3beta,16alpha,17beta-trihydroxyandrost-5-ene + NAD(P)+
show the reaction diagram
-
low activity
-
?
estra-1,3,5(10)-triene-3,16beta,17beta-triol + NAD(P)+
estra-1,3,5(10)-triene-3,17beta-diol-16-one + NAD(P)H
show the reaction diagram
-
-
-
?
estra-1,3,5(10)triene-3,17-beta-diol-16-one + NAD(P)H
estra-1,3,5(10)triene-3,16alpha,17-triol + NAD(P)+
show the reaction diagram
-
low activity
-
r