Sequence of PDE10_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3',5'-cyclic-nucleotide phosphodiesterase
Q9Y233
Homo sapiens
779
88412
Reaction
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MRIEERKSQH LTGLTDEKVK AYLSLHPQVL DEFVSESVSA ETVEKWLKRK NNKSEDESAP
 60 KEVSRYQDTN MQGVVYELNS YIEQRLDTGG DNQLLLYELS SIIKIATKAD GFALYFLGEC
120 NNSLCIFTPP GIKEGKPRLI PAGPITQGTT VSAYVAKSRK TLLVEDILGD ERFPRGTGLE
180 SGTRIQSVLC LPIVTAIGDL IGILELYRHW GKEAFCLSHQ EVATANLAWA SVAIHQVQVC
240 RGLAKQTELN DFLLDVSKTY FDNIVAIDSL LEHIMIYAKN LVNADRCALF QVDHKNKELY
300 SDLFDIGEEK EGKPVFKKTK EIRFSIEKGI AGQVARTGEV LNIPDAYADP RFNREVDLYT
360 GYTTRNILCM PIVSRGSVIG VVQMVNKISG SAFSKTDENN FKMFAVFCAL ALHCANMYHR
420 IRHSECIYRV TMEKLSYHSI CTSEEWQGLM QFTLPVRLCK EIELFHFDIG PFENMWPGIF
480 VYMVHRSCGT SCFELEKLCR FIMSVKKNYR RVPYHNWKHA VTVAHCMYAI LQNNHTLFTD
540 LERKGLLIAC LCHDLDHRGF SNSYLQKFDH PLAALYSTST MEQHHFSQTV SILQLEGHNI
600 FSTLSSSEYE QVLEIIRKAI IATDLALYFG NRKQLEEMYQ TGSLNLNNQS HRDRVIGLMM
660 TACDLCSVTK LWPVTKLTAN DIYAEFWAEG DEMKKLGIQP IPMMDRDKKD EVPQGQLGFY
720 NAVAIPCYTT LTQILPPTEP LLKACRDNLS QWEKVIRGEE TATWISSPSV AQKAAASED
Download this sequence
in fasta format
Download all sequences for 3.1.4.17
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
440733
Kotera J.,Fujishige K.,Yuasa K.,Omori K.
Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.
Biochem. Biophys. Res. Commun.
261
551-557
1999
440734
Fujishige K.,Kotera J.,Michibata H.,Yuasa K.,Takebayashi S.,Okumura K.,Omori K.
Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).
J. Biol. Chem.
274
18438-18445
1999
440735
Loughney K.,Snyder P.B.,Uher L.,Rosman G.J.,Ferguson K.,Florio V.A.
Isolation and characterization of PDE10A, a novel human 3',5'-cyclic nucleotide phosphodiesterase.
Gene
234
109-117
1999
440737
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
440738
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
440739
Fujishige K.,Kotera J.,Yuasa K.,Omori K.
The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains.
Eur. J. Biochem.
267
5943-5951
2000
440740
Gross-Langenhoff M.,Hofbauer K.,Weber J.,Schultz A.,Schultz J.E.
cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.
J. Biol. Chem.
281
2841-2846
2006
440741
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
440742
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
440743
Diggle C.P.,Sukoff Rizzo S.J.,Popiolek M.,Hinttala R.,Schuelke J.P.,Kurian M.A.,Carr I.M.,Markham A.F.,Bonthron D.T.,Watson C.,Sharif S.M.,Reinhart V.,James L.C.,Vanase-Frawley M.A.,Charych E.,Allen M.,Harms J.,Schmidt C.J.,Ng J.,Pysden K.,Strick C.,Vieira P.,Mankinen K.,Kokkonen H.,Kallioinen M.,Sormunen R.,Rinne J.O.,Johansson J.,Alakurtti K.,Huilaja L.,Hurskainen T.,Tasanen K.,Anttila E.,Marques T.R.,Howes O.,Politis M.,Fahiminiya S.,Nguyen K.Q.,Majewski J.,Uusimaa J.,Sheridan E.,Brandon N.J.
Biallelic mutations in PDE10A Lead to loss of striatal PDE10A and a hyperkinetic movement disorder with onset in infancy.
Am. J. Hum. Genet.
98
735-743
2016
440744
Mencacci N.E.,Kamsteeg E.J.,Nakashima K.,R'Bibo L.,Lynch D.S.,Balint B.,Willemsen M.A.,Adams M.E.,Wiethoff S.,Suzuki K.,Davies C.H.,Ng J.,Meyer E.,Veneziano L.,Giunti P.,Hughes D.,Raymond F.L.,Carecchio M.,Zorzi G.,Nardocci N.,Barzaghi C.,Garavaglia B.,Salpietro V.,Hardy J.,Pittman A.M.,Houlden H.,Kurian M.A.,Kimura H.,Vissers L.E.,Wood N.W.,Bhatia K.P.
De novo mutations in PDE10A cause childhood-onset chorea with bilateral striatal lesions.
Am. J. Hum. Genet.
98
763-771
2016
440745
Wang H.,Liu Y.,Hou J.,Zheng M.,Robinson H.,Ke H.
Structural insight into substrate specificity of phosphodiesterase 10.
Proc. Natl. Acad. Sci. U.S.A.
104
5782-5787
2007
440746
Handa N.,Mizohata E.,Kishishita S.,Toyama M.,Morita S.,Uchikubo-Kamo T.,Akasaka R.,Omori K.,Kotera J.,Terada T.,Shirouzu M.,Yokoyama S.
Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP.
J. Biol. Chem.
283
19657-19664
2008