Sequence of KSYK_MOUSE
EC Number:2.7.10.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2
General information:
Sequence
0 MAGSAVDSAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA
60 HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPDGLIC LLKKPFNRPP GVQPKTGPFE
120 DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT
180 VLIGSKTNGK FLIRARDNSG SYALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV
240 EHYSYKPDGL LRVLTVPCQK IGAQMGHPGS PNAHPVTWSP GGIISRIKSY SFPKPGHKKP
300 APPQGSRPES TVSFNPYEPT GGPWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD
360 RSLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ
420 LDNPYIVRMI GICEAESWML VMEMAELGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE
480 ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY
540 YKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPAG CPREMYDLMN
600 LCWTYDVENR PGFTAVELRL RNYYYDVVN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
435730
Turner M.,Mee P.J.,Costello P.S.,Williams O.,Price A.A.,Duddy L.P.,Furlong M.T.,Geahlen R.L.,Tybulewicz V.L.
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
Nature
378
298-302
1995
435731
Flueck M.,Zuercher G.,Andres A.,Ziemiecki A.
Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein.
Biochem. Biophys. Res. Commun.
213
273-281
1995
435733
Kurosaki T.,Takata M.,Yamanashi Y.,Inazu T.,Taniguchi T.,Yamamoto T.,Yamamura H.
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.
J. Exp. Med.
179
1725-1729
1994
435734
Rowley R.B.,Burkhardt A.L.,Chao H.-G.,Matsueda G.R.,Bolen J.B.
Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.
J. Biol. Chem.
270
11590-11594
1995
435735
Cheng A.M.,Rowley B.,Pao W.,Hayday A.,Bolen J.B.,Pawson T.
Syk tyrosine kinase required for mouse viability and B-cell development.
Nature
378
303-306
1995
435736
Poole A.,Gibbins J.M.,Turner M.,van Vugt M.J.,van de Winkel J.G.,Saito T.,Tybulewicz V.L.,Watson S.P.
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
EMBO J.
16
2333-2341
1997
435737
Vines C.M.,Potter J.W.,Xu Y.,Geahlen R.L.,Costello P.S.,Tybulewicz V.L.,Lowell C.A.,Chang P.W.,Gresham H.D.,Willman C.L.
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
Immunity
15
507-519
2001
435738
Hong J.J.,Yankee T.M.,Harrison M.L.,Geahlen R.L.
Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.
J. Biol. Chem.
277
31703-31714
2002
435739
Obergfell A.,Eto K.,Mocsai A.,Buensuceso C.,Moores S.L.,Brugge J.S.,Lowell C.A.,Shattil S.J.
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
J. Cell Biol.
157
265-275
2002
435740
Sohn H.W.,Gu H.,Pierce S.K.
Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.
J. Exp. Med.
197
1511-1524
2003
435741
Abtahian F.,Guerriero A.,Sebzda E.,Lu M.M.,Zhou R.,Mocsai A.,Myers E.E.,Huang B.,Jackson D.G.,Ferrari V.A.,Tybulewicz V.,Lowell C.A.,Lepore J.J.,Koretzky G.A.,Kahn M.L.
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
Science
299
247-251
2003
435742
Ohtsuka M.,Arase H.,Takeuchi A.,Yamasaki S.,Shiina R.,Suenaga T.,Sakurai D.,Yokosuka T.,Arase N.,Iwashima M.,Kitamura T.,Moriya H.,Saito T.
NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.
Proc. Natl. Acad. Sci. U.S.A.
101
8126-8131
2004
435743
Underhill D.M.,Rossnagle E.,Lowell C.A.,Simmons R.M.
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Blood
106
2543-2550
2005
435744
Rogers N.C.,Slack E.C.,Edwards A.D.,Nolte M.A.,Schulz O.,Schweighoffer E.,Williams D.L.,Gordon S.,Tybulewicz V.L.,Brown G.D.,Reis e Sousa C.
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
Immunity
22
507-517
2005
435745
Suzuki-Inoue K.,Fuller G.L.J.,Garcia A.,Eble J.A.,Poehlmann S.,Inoue O.,Gartner T.K.,Hughan S.C.,Pearce A.C.,Laing G.D.,Theakston R.D.G.,Schweighoffer E.,Zitzmann N.,Morita T.,Tybulewicz V.L.J.,Ozaki Y.,Watson S.P.
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
Blood
107
542-549
2006
435746
Yu M.,Lowell C.A.,Neel B.G.,Gu H.
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
J. Immunol.
176
2421-2429
2006
435747
Mocsai A.,Abram C.L.,Jakus Z.,Hu Y.,Lanier L.L.,Lowell C.A.
Integrin signaling in neutrophils and macrophages uses adapters containing immunoreceptor tyrosine-based activation motifs.
Nat. Immunol.
7
1326-1333
2006
435748
Zou W.,Kitaura H.,Reeve J.,Long F.,Tybulewicz V.L.,Shattil S.J.,Ginsberg M.H.,Ross F.P.,Teitelbaum S.L.
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
J. Cell Biol.
176
877-888
2007
435749
Cao L.,Yu K.,Banh C.,Nguyen V.,Ritz A.,Raphael B.J.,Kawakami Y.,Kawakami T.,Salomon A.R.
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
J. Immunol.
179
5864-5876
2007
435750
Kulathu Y.,Hobeika E.,Turchinovich G.,Reth M.
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.
EMBO J.
27
1333-1344
2008
435751
Van Ziffle J.A.,Lowell C.A.
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
Blood
114
4871-4882
2009
435752
Oda H.,Fujimoto M.,Patrick M.S.,Chida D.,Sato Y.,Azuma Y.,Aoki H.,Abe T.,Suzuki H.,Shirai M.
RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
J. Immunol.
182
957-962
2009
435753
Gross O.,Poeck H.,Bscheider M.,Dostert C.,Hannesschlaeger N.,Endres S.,Hartmann G.,Tardivel A.,Schweighoffer E.,Tybulewicz V.,Mocsai A.,Tschopp J.,Ruland J.
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Nature
459
433-436
2009
435754
Sancho D.,Joffre O.P.,Keller A.M.,Rogers N.C.,Martinez D.,Hernanz-Falcon P.,Rosewell I.,Reis e Sousa C.
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
Nature
458
899-903
2009
435755
Hida S.,Yamasaki S.,Sakamoto Y.,Takamoto M.,Obata K.,Takai T.,Karasuyama H.,Sugane K.,Saito T.,Taki S.
Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.
Nat. Immunol.
10
214-222
2009
435756
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
435757
Lu R.,Pan H.,Shively J.E.
CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.
PLoS Pathog.
8
0-0
2012
435758
Murata Y.,Kotani T.,Supriatna Y.,Kitamura Y.,Imada S.,Kawahara K.,Nishio M.,Daniwijaya E.W.,Sadakata H.,Kusakari S.,Mori M.,Kanazawa Y.,Saito Y.,Okawa K.,Takeda-Morishita M.,Okazawa H.,Ohnishi H.,Azuma T.,Suzuki A.,Matozaki T.
Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
Proc. Natl. Acad. Sci. U.S.A.
112
0-0
2015
435759
Wang L.,Aschenbrenner D.,Zeng Z.,Cao X.,Mayr D.,Mehta M.,Capitani M.,Warner N.,Pan J.,Wang L.,Li Q.,Zuo T.,Cohen-Kedar S.,Lu J.,Ardy R.C.,Mulder D.J.,Dissanayake D.,Peng K.,Huang Z.,Li X.,Wang Y.,Wang X.,Li S.,Bullers S.,Gammage A.N.,Warnatz K.,Schiefer A.I.,Krivan G.,Goda V.,Kahr W.H.A.,Lemaire M.,Lu C.Y.,Siddiqui I.,Surette M.G.,Kotlarz D.,Engelhardt K.R.,Griffin H.R.,Rottapel R.,Decaluwe H.,Laxer R.M.,Proietti M.,Hambleton S.,Elcombe S.,Guo C.H.,Grimbacher B.,Dotan I.,Ng S.C.,Freeman S.A.,Snapper S.B.,Klein C.,Boztug K.,Huang Y.,Li D.,Uhlig H.H.,Muise A.M.
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
Nat. Genet.
53
500-510
2021
