Sequence of FAS_RAT
EC Number:2.3.1.85
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
Other sequences found for EC No. 2.3.1.85
General information:
Sequence
0 MEEVVIAGMS GKLPESENLQ EFWANLIGGV DMVTDDDRRW KAGLYGLPKR SGKLKDLSKF
60 DASFFGVHPK QAHTMDPQLR LLLEVSYEAI VDGGINPASL RGTNTGVWVG VSGSEASEAL
120 SRDPETLLGY SMVGCQRAMM ANRLSFFFDF KGPSIALDTA CSSSLLALQN AYQAIRSGEC
180 PAAIVGGINL LLKPNTSVQF MKLGMLSPDG TCRSFDDSGN GYCRAEAVVA VLLTKKSLAR
240 RVYATILNAG TNTDGCKEQG VTFPSGEAQE QLIRSLYQPG GVAPESLEYI EAHGTGTKVG
300 DPQELNGITR SLCAFRQSPL LIGSTKSNMG HPEPASGLAA LTKVLLSLEN GVWAPNLHFH
360 NPNPEIPALL DGRLQVVDRP LPVRGGIVGI NSFGFGGANV HVILQPNTQQ APAPAPHAAL
420 PHLLHASGRT MEAVQGLLEQ GRQHSQDLAF VSMLNDIAAT PTAAMPFRGY TVLGVEGHVQ
480 EVQQVPASQR PLWFICSGMG TQWRGMGLSL MRLDSFRESI LRSDEALKPL GVKVSDLLLS
540 TDEHTFDDIV HSFVSLTAIQ IALIDLLTSM GLKPDGIIGH SLGEVACGYA DGCLSQREAV
600 LAAYWRGQCI KDANLPAGSM AAVGLSWEEC KQRCPPGVVP ACHNSEDTVT ISGPQAAVNE
660 FVEQLKQEGV FAKEVRTGGL AFHSYFMEGI APTLLQALKK VIREPRPRSA RWLSTSIPEA
720 QWQSSLARTS SAEYNVNNLV SPVLFQEALW HVPEHAVVLE IAPHALLQAV LKRGVKPSCT
780 IIPLMKRDHK DNLEFFLTNL GKVHLTGIDI NPNALFPPVE FPVPRGTPLI SPHIKWDHSQ
840 TWDIPVAEDF PNGSSSSSAT VYNIDASSES SDHYLVDHCI DGRVLFPGTG YLYLVWKTLA
900 RSLSLSLEET PVVFENVTFH QATILPRTGT VPLEVRLLEA SHAFEVSDSG NLIVSGKVYQ
960 WEDPDSKLFD HPEVPIPAES ESVSRLTQGE VYKELRLRGY DYGPHFQGVY EATLEGEQGK
1020 LLWKDNWVTF MDTMLQISIL GFSKQSLQLP TRVTAIYIDP ATHLQKVYML EGDTQVADVT
1080 TSRCLGVTVS GGVYISRLQT TATSRRQQEQ LVPTLEKFVF TPHVEPECLS ESAILQKELQ
1140 LCKGLAKALQ TKATQQGLKM TVPGLEDLPQ HGLPRLLAAA CQLQLNGNLQ LELGEVLARE
1200 RLLLPEDPLI SGLLNSQALK ACIDTALENL STLKMKVVEV LAGEGHLYSH ISALLNTQPM
1260 LQLEYTATDR HPQALKDVQT KLQQHDVAQG QWDPSGPAPT NLGALDLVVC NCALATLGDP
1320 ALALDNMVAA LKDGGFLLMH TVLKGHALGE TLACLPSEVQ PGPSFLSQEE WESLFSRKAL
1380 HLVGLKKSFY GTALFLCRRL SPQDKPIFLP VEDTSFQWVD SLKSILATSS SQPVWLTAMN
1440 CPTSGVVGLV NCLRKEPGGH RIRCILLSNL SSTSHVPKLD PGSSELQKVL ESDLVMNVYR
1500 DGAWGAFRHF QLEQDKPEEQ TAHAFVNVLT RGDLASIRWV SSPLKHMQPP SSSGAQLCTV
1560 YYASLNFRDI MLATGKLSPD AIPGKWASRD CMLGMEFSGR DKCGRRVMGL VPAEGLATSV
1620 LLSPDFLWDV PSSWTLEEAA SVPVVYTTAY YSLVVRGRIQ HGETVLIHSG SGGVGQAAIS
1680 IALSLGCRVF TTVGSAEKRA YLQARFPQLD DTSFANSRDT SFEQHVLLHT GGKGVDLVLN
1740 SLAEEKLQAS VRCLAQHGRF LEIGKFDLSN NHPLGMAIFL KNVTFHGILL DALFEGANDS
1800 WREVAELLKA GIRDGVVKPL KCTVFPKAQV EDAFRYMAQG KHIGKVLVQV REEEPEAMLP
1860 GAQPTLISAI SKTFCPEHKS YIITGGLGGF GLELARWLVL RGAQRLVLTS RSGIRTGYQA
1920 KHVREWRRQG IHVLVSTSNV SSLEGARALI AEATKLGPVG GVFNLAMVLR DAMLENQTPE
1980 LFQDVNKPKY NGTLNLDRAT REACPELDYF VAFSSVSCGR GNAGQSNYGF ANSTMERICE
2040 QRRHDGLPGL AVQWGAIGDV GIILEAMGTN DTVVGGTLPQ RISSCMEVLD LFLNQPHAVL
2100 SSFVLAEKKA VAHGDGEAQR DLVKAVAHIL GIRDLAGINL DSSLADLGLD SLMGVEVRQI
2160 LEREHDLVLP IREVRQLTLR KLQEMSSKAG SDTELAAPKS KNDTSLKQAQ LNLSILLVNP
2220 EGPTLTRLNS VQSSERPLFL VHPIEGSITV FHSLAAKLSV PTYGLQCTQA APLDSIPNLA
2280 AYYIDCIKQV QPEGPYRVAG YSFGACVAFE MCSQLQAQQG PAPAHNNLFL FDGSHTYVLA
2340 YTQSYRAKLT PGCEAEAEAE AICFFIKQFV DAEHSKVLEA LLPLKSLEDR VAAAVDLITR
2400 SHQSLDRRDL SFAAVSFYYK LRAADQYKPK AKYHGNVILL RAKTGGTYGE DLGADYNLSQ
2460 VCDGKVSVHI IEGDHRTLLE GRGLESIINI IHSSLAEPRV SVREG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
416783
Amy C.M.,Witkowski A.,Naggert J.,Williams B.,Randhawa Z.,Smith S.
Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.
Proc. Natl. Acad. Sci. U.S.A.
86
3114-3118
1989
416784
Beck K.F.,Schreglmann R.,Stathopulos I.,Klein H.,Hoch J.,Schweizer M.
The fatty acid synthase (FAS) gene and its promoter in Rattus norvegicus.
DNA Seq.
2
359-386
1992
416785
Amy C.M.,Williams-Ahlf B.,Naggert J.,Smith S.
Intron-exon organization of the gene for the multifunctional animal fatty acid synthase.
Proc. Natl. Acad. Sci. U.S.A.
89
1105-1108
1992
416786
Schweizer M.,Takabeyashi K.,Beck K.F.,Schreglmann R.
Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA.
Nucleic Acids Res.
17
567-586
1989
416787
Witlowski A.,Naggert J.,Mikkelsen J.,Smith S.
Molecular cloning and sequencing of a cDNA encoding the acyl carrier protein and its flanking domains in the mammalian fatty acid synthetase.
Eur. J. Biochem.
165
601-606
1987
416788
Naggert J.,Witkowski A.,Mikkelsen J.,Smith S.
Molecular cloning and sequencing of a cDNA encoding the thioesterase domain of the rat fatty acid synthetase.
J. Biol. Chem.
263
1146-1150
1988
416789
Clarke S.D.,Armstrong M.K.,Jump D.B.
Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance.
J. Nutr.
120
218-224
1990
416790
Joshi A.K.,Smith S.
Construction of a cDNA encoding the multifunctional animal fatty acid synthase and expression in Spodoptera frugiperda cells using baculoviral vectors.
Biochem. J.
296
143-149
1993
416791
Witkowski A.,Joshi A.,Smith S.
Fatty acid synthase: in vitro complementation of inactive mutants.
Biochemistry
35
10569-10575
1996
416792
Witkowski A.,Joshi A.K.,Smith S.
Characterization of the interthiol acyltransferase reaction catalyzed by the beta-ketoacyl synthase domain of the animal fatty acid synthase.
Biochemistry
36
16338-16344
1997
416793
Rendina A.R.,Cheng D.
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates.
Biochem. J.
388
895-903
2005
416794
Najjar S.M.,Yang Y.,Fernstroem M.A.,Lee S.J.,Deangelis A.M.,Rjaily G.A.,Al-Share Q.Y.,Dai T.,Miller T.A.,Ratnam S.,Ruch R.J.,Smith S.,Lin S.H.,Beauchemin N.,Oyarce A.M.
Insulin acutely decreases hepatic fatty acid synthase activity.
Cell Metab.
2
43-53
2005
416795
Zhao W.,Kridel S.,Thorburn A.,Kooshki M.,Little J.,Hebbar S.,Robbins M.
Fatty acid synthase: a novel target for antiglioma therapy.
Br. J. Cancer
95
869-878
2006
416796
Pasta S.,Witkowski A.,Joshi A.K.,Smith S.
Catalytic residues are shared between two pseudosubunits of the dehydratase domain of the animal fatty acid synthase.
Chem. Biol.
14
1377-1385
2007
416797
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
416798
Reed M.A.C.,Schweizer M.,Szafranska A.E.,Arthur C.,Nicholson T.P.,Cox R.J.,Crosby J.,Crump M.P.,Simpson T.J.
The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs.
Org. Biomol. Chem.
1
463-471
2003
